Delayed-hypersensitivity skin-tests in prognosis of human-immunodeficiency-virus infection

Delayed-hypersensitivity skin-tests in prognosis of human-immunodeficiency-virus infection

Author Zeballos, R. S. Google Scholar
Cavalcante, N. Google Scholar
Freire, Carlos Alberto Reis Autor UNIFESP Google Scholar
Hernandez, H. J. Google Scholar
Longo, I. M. Google Scholar
Peixinho, Z. F. Google Scholar
Moura, N. C. Google Scholar
Mendes, N. F. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Delayed hypersensitivity skin tests (DHST) with recall antigens were investigated as prognostic markers in five different approaches. in the first study, 42 acquired immunodeficiency syndrome (AIDS) patients (IVb, IVcl, IVd, and IVe; MMWR 35:334-339,1986) 26 AIDS-related complex (ARC) patients (IVa and IVc2), and 98 asymptomatic patients (II and III) were evaluated with candidin, tricophytin, PPD and streptokinase-streptodornase. in the second study, 10 patients (II and III) were evaluated sequentially with the same antigens. in the third, 45 patients with at least two positive skin tests (reactors) were followed for one year and evaluated every 6 months with the same antigens. in the fourth, 16 reactors were followed and evaluated every 3 months with the same antigens. We measured the interval from the time at which patients first presented with only one or no positive DHST until the development of ARC or AIDS. in the last study, the correlation between absolute number of CD4+ lymphocytes and the number of DHST was studied in 151 patients. We found that the decrease in reactiveness to DHST correlated directly with the progression to AIDS, demonstrating the usefulness of this simple procedure as a valid prognostic marker.
Keywords DHST
HIV
AIDS
Language English
Date 1992-01-01
Published in Journal of Clinical Laboratory Analysis. New York: Wiley-liss, v. 6, n. 3, p. 119-122, 1992.
ISSN 0887-8013 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 119-122
Origin http://dx.doi.org/10.1002/jcla.1860060303
Access rights Closed access
Type Article
Web of Science ID WOS:A1992HR20300002
URI http://repositorio.unifesp.br/handle/11600/25234

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