Delayed-hypersensitivity skin-tests in prognosis of human-immunodeficiency-virus infection

Delayed-hypersensitivity skin-tests in prognosis of human-immunodeficiency-virus infection

Autor Zeballos, R. S. Google Scholar
Cavalcante, N. Google Scholar
Freire, Carlos Alberto Reis Autor UNIFESP Google Scholar
Hernandez, H. J. Google Scholar
Longo, I. M. Google Scholar
Peixinho, Z. F. Google Scholar
Moura, N. C. Google Scholar
Mendes, N. F. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Delayed hypersensitivity skin tests (DHST) with recall antigens were investigated as prognostic markers in five different approaches. in the first study, 42 acquired immunodeficiency syndrome (AIDS) patients (IVb, IVcl, IVd, and IVe; MMWR 35:334-339,1986) 26 AIDS-related complex (ARC) patients (IVa and IVc2), and 98 asymptomatic patients (II and III) were evaluated with candidin, tricophytin, PPD and streptokinase-streptodornase. in the second study, 10 patients (II and III) were evaluated sequentially with the same antigens. in the third, 45 patients with at least two positive skin tests (reactors) were followed for one year and evaluated every 6 months with the same antigens. in the fourth, 16 reactors were followed and evaluated every 3 months with the same antigens. We measured the interval from the time at which patients first presented with only one or no positive DHST until the development of ARC or AIDS. in the last study, the correlation between absolute number of CD4+ lymphocytes and the number of DHST was studied in 151 patients. We found that the decrease in reactiveness to DHST correlated directly with the progression to AIDS, demonstrating the usefulness of this simple procedure as a valid prognostic marker.
Palavra-chave DHST
HIV
AIDS
Idioma Inglês
Data de publicação 1992-01-01
Publicado em Journal of Clinical Laboratory Analysis. New York: Wiley-liss, v. 6, n. 3, p. 119-122, 1992.
ISSN 0887-8013 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 119-122
Fonte http://dx.doi.org/10.1002/jcla.1860060303
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1992HR20300002
Endereço permanente http://repositorio.unifesp.br/handle/11600/25234

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