EFFECTS of SINGLE and LONG-TERM DROPERIDOL ADMINISTRATION ON OPEN-FIELD and STEREOTYPED BEHAVIOR of RATS

EFFECTS of SINGLE and LONG-TERM DROPERIDOL ADMINISTRATION ON OPEN-FIELD and STEREOTYPED BEHAVIOR of RATS

Autor Frussafilho, R. Google Scholar
Palermoneto, J. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
SCH MED MARILIA
Resumo The effects of single and long-term droperidol administration on rat open-field and apomorphine-induced stereotyped behavior were studied. A single dose of droperidol decreased dose dependently not only locomotion and rearing frequencies in the open-field but also the apomorphine effects. Long-term droperidol administration induced significant tolerance to all parameters of activity recorded in the open-field. Unlike other dopamine blockers, droperidol withdrawn from long-term droperidol administration wasn't able to increase rats' open-field parameters significantly. However, like other dopamine blockers, droperidol withdrawn produced an augmented responsiveness to apomorphine-induced stereotyped behavior. These results suggest that the supersensitivity of central dopamine receptors developed after droperidol treatment may have peculiar characteristics.
Palavra-chave DROPERIDOL
DOPAMINERGIC SUPERSENSITIVITY
OPEN-FIELD
DRUG WITHDRAWAL
STEREOTYPY
GENERAL ACTIVITY
Idioma Inglês
Data de publicação 1991-10-01
Publicado em Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 50, n. 4, p. 825-830, 1991.
ISSN 0031-9384 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 825-830
Fonte http://dx.doi.org/10.1016/0031-9384(91)90024-I
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1991GN34700024
Endereço permanente http://repositorio.unifesp.br/handle/11600/25221

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