VERY-LOW DOSE ANTACID in TREATMENT of DUODENAL-ULCER - COMPARISON WITH CIMETIDINE

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dc.contributor.author Zaterka, S.
dc.contributor.author Cordeiro, F. F.
dc.contributor.author Lyra, LGC
dc.contributor.author Toletino, M. M.
dc.contributor.author Miszputen, S. J.
dc.contributor.author Jorge, J. L.
dc.contributor.author Silva, E. P.
dc.contributor.author Vieira, F. E.
dc.contributor.author Modena, J. L.
dc.contributor.author Massuda, H. K.
dc.contributor.author Eisig, J. N.
dc.contributor.author Chinzon, D.
dc.contributor.author Pereira, A. A.
dc.contributor.author Altieri, L.
dc.contributor.author Gantois, C. E.
dc.contributor.author Wilson, R. B.
dc.contributor.author Martins, MCB
dc.contributor.author Rosa, H.
dc.contributor.author Neto, E. D.
dc.date.accessioned 2016-01-24T11:40:04Z
dc.date.available 2016-01-24T11:40:04Z
dc.date.issued 1991-10-01
dc.identifier http://dx.doi.org/10.1007/BF01296802
dc.identifier.citation Digestive Diseases and Sciences. New York: Plenum Publ Corp, v. 36, n. 10, p. 1377-1383, 1991.
dc.identifier.issn 0163-2116
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25220
dc.description.abstract Antacid (AA) in a very low dose (88 mmol/day) was compared to the standard 800-mg dose of cimetidine in healing duodenal ulcers. the influence of sex, age, symptom duration at entry, night pain, smoking, coffee consumption, and alcohol on ulcer healing was studied. the antacid was given in two different schedules: group I-20 ml 1 hr after breakfast and at bedtime; group II-10 ml 1 hr after breakfast and lunch and 20 ml at bedtime. Cimetidine (group III) was given in two divided doses: 400 mg 1 hr after breakfast and 400 mg at bedtime. Endoscopic control was performed after four weeks and, if necessary, after eight weeks of treatment. the healing rate after four weeks of treatment was, respectively, for groups I, II, and III, 45.5%, 55.8%, and 69.4% (group I = group II, and group III different from groups I and II). After eight weeks of treatment the healing rate was 61.5%, 80.8%, and 88.0% for groups I, II, and III, respectively (group II = group III, and group I different from groups II and III). Except for group I, smoking did not influence healing rate. Age sex, symptoms at entry, night pain, and coffee consumption did not influence the treatment results. the authors concluded that the very low dose of magaldrate (88 mmol/day), when administered in three divided doses (10 ml after breakfast and lunch and 20 ml at bedtime) for eight weeks was as effective as 800 mg of cimetidine (400 mg twice a day) in healing duodenal ulcer. en
dc.format.extent 1377-1383
dc.language.iso eng
dc.publisher Plenum Publ Corp
dc.relation.ispartof Digestive Diseases and Sciences
dc.rights Acesso restrito
dc.subject ANTACIDS en
dc.subject CIMETIDINE en
dc.subject H-2 BLOCKERS en
dc.subject DUODENAL ULCERS en
dc.title VERY-LOW DOSE ANTACID in TREATMENT of DUODENAL-ULCER - COMPARISON WITH CIMETIDINE en
dc.type Artigo
dc.contributor.institution HOSP CLIN SALVADOR
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution HOSP STA JOANA
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution HOSP PORTUGUES
dc.contributor.institution UNIDADE GASTROENTEROL
dc.contributor.institution HOSP CELSO RAMOS
dc.contributor.institution HOSP STA ISABEL
dc.contributor.institution FAC MED RIBEIRAO PRETO
dc.contributor.institution Universidade Federal de Goiás (UFG)
dc.description.affiliation HOSP CLIN SALVADOR,SALVADOR,BRAZIL
dc.description.affiliation ESCOLA PAULISTA MED SCH,BR-04023 São Paulo,BRAZIL
dc.description.affiliation HOSP STA JOANA,RECIFE,BRAZIL
dc.description.affiliation UNIV São Paulo,FAC MED,São Paulo,BRAZIL
dc.description.affiliation HOSP PORTUGUES,RECIFE,BRAZIL
dc.description.affiliation UNIDADE GASTROENTEROL,BAURU,BRAZIL
dc.description.affiliation HOSP CELSO RAMOS,FLORIANOPOLIS,BRAZIL
dc.description.affiliation HOSP STA ISABEL,BLUMENAU,BRAZIL
dc.description.affiliation FAC MED RIBEIRAO PRETO,TRIBEIRAO PRETO,BRAZIL
dc.description.affiliation UNIV FED GOIAS,GOIANIA,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED SCH,BR-04023 São Paulo,BRAZIL
dc.identifier.doi 10.1007/BF01296802
dc.description.source Web of Science
dc.identifier.wos WOS:A1991GM08700006



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