VERY-LOW DOSE ANTACID in TREATMENT of DUODENAL-ULCER - COMPARISON WITH CIMETIDINE

VERY-LOW DOSE ANTACID in TREATMENT of DUODENAL-ULCER - COMPARISON WITH CIMETIDINE

Autor Zaterka, S. Google Scholar
Cordeiro, F. F. Google Scholar
Lyra, LGC Google Scholar
Toletino, M. M. Google Scholar
Miszputen, S. J. Google Scholar
Jorge, J. L. Google Scholar
Silva, E. P. Google Scholar
Vieira, F. E. Google Scholar
Modena, J. L. Google Scholar
Massuda, H. K. Google Scholar
Eisig, J. N. Google Scholar
Chinzon, D. Google Scholar
Pereira, A. A. Google Scholar
Altieri, L. Google Scholar
Gantois, C. E. Google Scholar
Wilson, R. B. Google Scholar
Martins, MCB Google Scholar
Rosa, H. Google Scholar
Neto, E. D. Google Scholar
Instituição HOSP CLIN SALVADOR
Universidade Federal de São Paulo (UNIFESP)
HOSP STA JOANA
Universidade de São Paulo (USP)
HOSP PORTUGUES
UNIDADE GASTROENTEROL
HOSP CELSO RAMOS
HOSP STA ISABEL
FAC MED RIBEIRAO PRETO
Universidade Federal de Goiás (UFG)
Resumo Antacid (AA) in a very low dose (88 mmol/day) was compared to the standard 800-mg dose of cimetidine in healing duodenal ulcers. the influence of sex, age, symptom duration at entry, night pain, smoking, coffee consumption, and alcohol on ulcer healing was studied. the antacid was given in two different schedules: group I-20 ml 1 hr after breakfast and at bedtime; group II-10 ml 1 hr after breakfast and lunch and 20 ml at bedtime. Cimetidine (group III) was given in two divided doses: 400 mg 1 hr after breakfast and 400 mg at bedtime. Endoscopic control was performed after four weeks and, if necessary, after eight weeks of treatment. the healing rate after four weeks of treatment was, respectively, for groups I, II, and III, 45.5%, 55.8%, and 69.4% (group I = group II, and group III different from groups I and II). After eight weeks of treatment the healing rate was 61.5%, 80.8%, and 88.0% for groups I, II, and III, respectively (group II = group III, and group I different from groups II and III). Except for group I, smoking did not influence healing rate. Age sex, symptoms at entry, night pain, and coffee consumption did not influence the treatment results. the authors concluded that the very low dose of magaldrate (88 mmol/day), when administered in three divided doses (10 ml after breakfast and lunch and 20 ml at bedtime) for eight weeks was as effective as 800 mg of cimetidine (400 mg twice a day) in healing duodenal ulcer.
Palavra-chave ANTACIDS
CIMETIDINE
H-2 BLOCKERS
DUODENAL ULCERS
Idioma Inglês
Data de publicação 1991-10-01
Publicado em Digestive Diseases and Sciences. New York: Plenum Publ Corp, v. 36, n. 10, p. 1377-1383, 1991.
ISSN 0163-2116 (Sherpa/Romeo, fator de impacto)
Publicador Plenum Publ Corp
Extensão 1377-1383
Fonte http://dx.doi.org/10.1007/BF01296802
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1991GM08700006
Endereço permanente http://repositorio.unifesp.br/handle/11600/25220

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