IMMUNOHISTOCHEMICAL EVALUATION of UVEAL MELANOCYTIC TUMORS - EXPRESSION of HMB-45, S-100 PROTEIN, and NEURON-SPECIFIC ENOLASE

IMMUNOHISTOCHEMICAL EVALUATION of UVEAL MELANOCYTIC TUMORS - EXPRESSION of HMB-45, S-100 PROTEIN, and NEURON-SPECIFIC ENOLASE

Autor Burnier Junior, Miguel Noel Autor UNIFESP Google Scholar
Mclean, I. W. Google Scholar
Gamel, J. W. Google Scholar
Orientador Google Scholar
Instituição ARMED FORCES INST PATHOL
Universidade Federal de São Paulo (UNIFESP)
UNIV LOUISVILLE
Resumo The authors compared the immunohistochemical reactivity of 13 uveal nevi and 20 uveal melanomas for HMB-45, S-100 protein, and neuron-specific enolase (NSE) in formalin-fixed, paraffin-embedded sections. All 33 of the lesions were positive for HMB-45. the false-negative rates for S-100 protein and NSE were 21% and 18%, respectively. If only strongly positive reactions were considered, more than 50% of the tumors would be interpreted as negative for S-100 protein and NSE. Nevi stained with less intensity than melanomas using all three antibodies. the expression of HMB-45 appeared to be greater in active nevi than in inactive nevi. There was a weak association between S-100 protein reactivity and the ability of the uveal melanomas to metastasize (P = 0.1); however, the standard deviation of nucleolar area was a much better predictor (P = 0.02). These results indicate that pathologists will find HMB-45 to be a useful tool in differentiating uveal melanoma from nonmelanocytic tumors.
Idioma Inglês
Data 1991-08-15
Publicado em Cancer. New York: Wiley-liss, v. 68, n. 4, p. 809-814, 1991.
ISSN 0008-543X (Sherpa/Romeo, fator de impacto)
Editor Wiley-Blackwell
Extensão 809-814
Fonte http://dx.doi.org/10.1002/1097-0142(19910815)68:4<809
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:A1991FY94700023
URI http://repositorio.unifesp.br/handle/11600/25214

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