Exposure and sensitization to dust mite allergens among asthmatic children in São Paulo, Brazil

Exposure and sensitization to dust mite allergens among asthmatic children in São Paulo, Brazil

Autor Arruda, Luisa Karla Google Scholar
Rizzo, Maria Candida Faria Varanda Autor UNIFESP Google Scholar
Chapman, Martin D. Google Scholar
Fernández-Caldas, Enrique Google Scholar
Baggio, D. Google Scholar
Plattsmills, Thomas AE Google Scholar
Naspitz, Charles Kirov Autor UNIFESP Google Scholar
Instituição UNIV S FLORIDA
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo A group of 20 mite allergic asthmatic children aged 6-12 years old, living in São Paulo, Brazil, was studied regarding their degree of sensitization to house dust mites and exposure to mite allergens in their homes. in 18 out of 20 houses at least one dust sample was obtained which contained > 10-mu-g Der p I/g of dust. the highest levels of Dermatophagoides pteronyssinus allergens, Der p I and Group II, were measured in bedding samples (geometric mean 38.4 and 36.6-mu-g/g, respectively), followed by bedroom floor, TV room and kitchen. Mite allergen levels in Brazilian houses were as high as those reported to be associated with sensitization and acute attacks of asthma in other parts of the world. in keeping with previous reports that D. farinae is rarely found in Brazil, Der fI was undetectable or found in very low levels (< 0.5-mu-g/g). Levels of cat allergen Fel d I of > 8-mu-g/g of dust were obtained only in 2 houses only. Cockroach allergen Bla g I was detected in five out of 20 houses. Levels of IgE antibodies to D. pteronyssinus were > 200 RAST U/ml in 19 out of 20 children (geometric mean 1588 RAST U/ml). IgE antibodies to cat, cockroach, A. fumigatus, ragweed and rye grass pollens were undetectable or < 80 RAST U/ml. IgE antibodies to the mite Blomia tropicalis were also measured, and levels > 200 RAST U/ml were observed in 13 out of 20 sera. Immunoabsorption studies demonstrated that the bulk of the IgE antibody to B. tropicalis (64%) was to species-specific allergens and that 36% were cross-reactive with D. pteronyssinus. the implication of our results is that management of children with asthma in São Paulo should include skin testing for allergy to both Dermatophagoides and B. tropicalis as well as recommendations about environmental control of house dust mite exposure.
Idioma Inglês
Data 1991-07-01
Publicado em Clinical and Experimental Allergy. Oxford: Blackwell Science Ltd, v. 21, n. 4, p. 433-439, 1991.
ISSN 0954-7894 (Sherpa/Romeo, fator de impacto)
Editor Blackwell Science Ltd
Extensão 433-439
Fonte http://dx.doi.org/10.1111/j.1365-2222.1991.tb01683.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1991FX10900007
URI http://repositorio.unifesp.br/handle/11600/25207

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