EFFECTS of SELECTIVE ADRENOCEPTOR AGONISTS and ANTAGONISTS ON AGGRESSIVE-BEHAVIOR ELICITED BY APOMORPHINE, DL-DOPA and FUSARIC ACID in REM-SLEEP-DEPRIVED RATS

Exibir registro simples

dc.contributor.author Troncone, LRP
dc.contributor.author Tufik, S.
dc.date.accessioned 2016-01-24T11:40:03Z
dc.date.available 2016-01-24T11:40:03Z
dc.date.issued 1991-07-01
dc.identifier http://dx.doi.org/10.1016/0031-9384(91)90517-R
dc.identifier.citation Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 50, n. 1, p. 173-178, 1991.
dc.identifier.issn 0031-9384
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25206
dc.description.abstract REM sleep deprivation (REMSD) results in behavioral changes such as the appearance of affective aggression induced by apomorphine (APO) and other dopaminergic agents. REMSD modifies dopamine-mediated behavior as well as the adrenergic receptor sensitivity. This paper evaluates the interaction between these two neurotransmission systems through changes in APO-, DL-DOPA- and fusaric acid (FA)-induced aggressive behavior in REMSD rats pretreated with phentolamine, propranolol, metaraminol, prazosin, clonidine, yohimbine, isoproterenol, butoxamine and maprotiline. Only isoproterenol reduced FA-induced aggressiveness. No specific changes in aggressiveness were noticed with other treatments and not even inhibitors of norepinephrine transmission induced aggressive behavior. It is concluded that norepinephrine had a slight inhibitory action on aggressiveness elicited by dopaminomimetic agents in REMSD rats. Beta-adrenoceptors could be responsible for this effect since only beta-selective drugs reduced aggression. As REMSD reduces beta-adrenoceptor sensitivity, only minor changes in aggressiveness could be observed. It was noted that the three drugs used to induce aggressive behavior elicited different patterns of aggression. en
dc.format.extent 173-178
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Physiology & Behavior
dc.rights Acesso restrito
dc.subject REM en
dc.subject SLEEP en
dc.subject DEPRIVATION en
dc.subject AFFECTIVE AGGRESSION en
dc.subject NOREPINEPHRINE en
dc.subject CATECHOLAMINES en
dc.subject ADRENERGICS en
dc.title EFFECTS of SELECTIVE ADRENOCEPTOR AGONISTS and ANTAGONISTS ON AGGRESSIVE-BEHAVIOR ELICITED BY APOMORPHINE, DL-DOPA and FUSARIC ACID in REM-SLEEP-DEPRIVED RATS en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation ESCOLA PAULISTA MED SCH,DEPT PSICOBIOL,BR-04023 São Paulo,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED SCH,DEPT PSICOBIOL,BR-04023 São Paulo,BRAZIL
dc.identifier.doi 10.1016/0031-9384(91)90517-R
dc.description.source Web of Science
dc.identifier.wos WOS:A1991GC29400029



Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Exibir registro simples

Buscar


Navegar

Minha conta