EFFECTS of SELECTIVE ADRENOCEPTOR AGONISTS and ANTAGONISTS ON AGGRESSIVE-BEHAVIOR ELICITED BY APOMORPHINE, DL-DOPA and FUSARIC ACID in REM-SLEEP-DEPRIVED RATS

EFFECTS of SELECTIVE ADRENOCEPTOR AGONISTS and ANTAGONISTS ON AGGRESSIVE-BEHAVIOR ELICITED BY APOMORPHINE, DL-DOPA and FUSARIC ACID in REM-SLEEP-DEPRIVED RATS

Author Troncone, LRP Google Scholar
Tufik, S. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract REM sleep deprivation (REMSD) results in behavioral changes such as the appearance of affective aggression induced by apomorphine (APO) and other dopaminergic agents. REMSD modifies dopamine-mediated behavior as well as the adrenergic receptor sensitivity. This paper evaluates the interaction between these two neurotransmission systems through changes in APO-, DL-DOPA- and fusaric acid (FA)-induced aggressive behavior in REMSD rats pretreated with phentolamine, propranolol, metaraminol, prazosin, clonidine, yohimbine, isoproterenol, butoxamine and maprotiline. Only isoproterenol reduced FA-induced aggressiveness. No specific changes in aggressiveness were noticed with other treatments and not even inhibitors of norepinephrine transmission induced aggressive behavior. It is concluded that norepinephrine had a slight inhibitory action on aggressiveness elicited by dopaminomimetic agents in REMSD rats. Beta-adrenoceptors could be responsible for this effect since only beta-selective drugs reduced aggression. As REMSD reduces beta-adrenoceptor sensitivity, only minor changes in aggressiveness could be observed. It was noted that the three drugs used to induce aggressive behavior elicited different patterns of aggression.
Keywords REM
SLEEP
DEPRIVATION
AFFECTIVE AGGRESSION
NOREPINEPHRINE
CATECHOLAMINES
ADRENERGICS
Language English
Date 1991-07-01
Published in Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 50, n. 1, p. 173-178, 1991.
ISSN 0031-9384 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 173-178
Origin http://dx.doi.org/10.1016/0031-9384(91)90517-R
Access rights Closed access
Type Article
Web of Science ID WOS:A1991GC29400029
URI http://repositorio.unifesp.br/handle/11600/25206

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