EFFECTS of SELECTIVE ADRENOCEPTOR AGONISTS and ANTAGONISTS ON AGGRESSIVE-BEHAVIOR ELICITED BY APOMORPHINE, DL-DOPA and FUSARIC ACID in REM-SLEEP-DEPRIVED RATS

EFFECTS of SELECTIVE ADRENOCEPTOR AGONISTS and ANTAGONISTS ON AGGRESSIVE-BEHAVIOR ELICITED BY APOMORPHINE, DL-DOPA and FUSARIC ACID in REM-SLEEP-DEPRIVED RATS

Autor Troncone, LRP Google Scholar
Tufik, S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo REM sleep deprivation (REMSD) results in behavioral changes such as the appearance of affective aggression induced by apomorphine (APO) and other dopaminergic agents. REMSD modifies dopamine-mediated behavior as well as the adrenergic receptor sensitivity. This paper evaluates the interaction between these two neurotransmission systems through changes in APO-, DL-DOPA- and fusaric acid (FA)-induced aggressive behavior in REMSD rats pretreated with phentolamine, propranolol, metaraminol, prazosin, clonidine, yohimbine, isoproterenol, butoxamine and maprotiline. Only isoproterenol reduced FA-induced aggressiveness. No specific changes in aggressiveness were noticed with other treatments and not even inhibitors of norepinephrine transmission induced aggressive behavior. It is concluded that norepinephrine had a slight inhibitory action on aggressiveness elicited by dopaminomimetic agents in REMSD rats. Beta-adrenoceptors could be responsible for this effect since only beta-selective drugs reduced aggression. As REMSD reduces beta-adrenoceptor sensitivity, only minor changes in aggressiveness could be observed. It was noted that the three drugs used to induce aggressive behavior elicited different patterns of aggression.
Palavra-chave REM
SLEEP
DEPRIVATION
AFFECTIVE AGGRESSION
NOREPINEPHRINE
CATECHOLAMINES
ADRENERGICS
Idioma Inglês
Data de publicação 1991-07-01
Publicado em Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 50, n. 1, p. 173-178, 1991.
ISSN 0031-9384 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 173-178
Fonte http://dx.doi.org/10.1016/0031-9384(91)90517-R
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1991GC29400029
Endereço permanente http://repositorio.unifesp.br/handle/11600/25206

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