EFFECTS of BILATERAL CLAMPING of CAROTID ARTERIES ON HIPPOCAMPAL KINDLING in RATS

EFFECTS of BILATERAL CLAMPING of CAROTID ARTERIES ON HIPPOCAMPAL KINDLING in RATS

Autor Bortolotto, Z. A. Google Scholar
Heim, C. Google Scholar
Sieklucka, M. Google Scholar
Block, F. Google Scholar
Sontag, K. H. Google Scholar
Cavalheiro, E. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
MAX PLANCK INST EXPTL MED
UNIV GOTTINGEN
INST CLIN PATHOL
Resumo Moderate reduction of cerebral blood flow by bilateral clamping of carotid arteries (BCCA) in pentobarbital anaesthetized Wistar rats induces decreased PO2 and temperature values in vulnerable brain structures such as hippocampus and frontal cortex during the acute phase of clamping. Up to two weeks chronic increased GABA contents in hippocampus, substantia nigra and frontal cortex could be observed. During this time the development of hippocampal kindling was difficult. These results demonstrated an acute and chronic influence of GABA on most vulnerable brain structures which, however, do not lead to ischemic impacts as histological analyses demonstrate.
Palavra-chave CEREBRAL BLOOD FLOW REDUCTION
GABA
HIPPOCAMPAL KINDLING
Idioma Inglês
Data de publicação 1991-04-01
Publicado em Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 49, n. 4, p. 667-671, 1991.
ISSN 0031-9384 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 667-671
Fonte http://dx.doi.org/10.1016/0031-9384(91)90299-4
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1991FL39200002
Endereço permanente http://repositorio.unifesp.br/handle/11600/25198

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