TRANSIENT OCCLUSION of RAT CAROTID ARTERIES DECREASES SUSCEPTIBILITY TO PILOCARPINE SEIZURES

TRANSIENT OCCLUSION of RAT CAROTID ARTERIES DECREASES SUSCEPTIBILITY TO PILOCARPINE SEIZURES

Autor Heim, C. Google Scholar
Bortolotto, Z. A. Google Scholar
Cavalheiro, E. A. Google Scholar
Sontag, K. H. Google Scholar
Instituição MAX PLANCK INST EXPTL MED
Universidade Federal de São Paulo (UNIFESP)
Resumo Bilateral clamping of the carotid arteries (BCCA) for 24 min protects animals against convulsive effects of intraperitoneal injection of 300 mg/kg of pilocarpine when administered 14 days after surgery. Electrographic recordings from hippocampus, frontal cortex, striatum and substantia nigra demonstrate that (1) no spontaneous spiking activity is caused by the BCCA when observed for up to 10 days after surgery, (2) spiking activity can only be recorded in limbic structures but not in the frontal cortex after systemic administration of pilocarpine. These observations suggest that the propagation of seizure activity from subcortical limbic structures to the neocortex is affected by BCCA.
Palavra-chave SEIZURE
PILOCARPINE
CAROTID ARTERIES OCCLUSION
ELECTROENCEPHALOGRAM
Idioma Inglês
Data de publicação 1991-03-29
Publicado em Brain Research. Amsterdam: Elsevier B.V., v. 544, n. 2, p. 253-259, 1991.
ISSN 0006-8993 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 253-259
Fonte http://dx.doi.org/10.1016/0006-8993(91)90062-Z
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1991FG19600011
Endereço permanente http://repositorio.unifesp.br/handle/11600/25194

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