INTERACTION AMONG ZINC, GLUCOSE, and INSULIN in NORMAL INDIVIDUALS DURING GLUCOSE and TOLBUTAMIDE PERFUSION

INTERACTION AMONG ZINC, GLUCOSE, and INSULIN in NORMAL INDIVIDUALS DURING GLUCOSE and TOLBUTAMIDE PERFUSION

Autor Neto, J. B. Google Scholar
Vieira, JGH Google Scholar
Shuhama, T. Google Scholar
Russo, EMK Google Scholar
Piesco, R. V. Google Scholar
Curi, P. R. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Reports in the literature have shown that acute or chronic zinc administration may cause hyperglycemia, with a fall in serum or insular insulin occurring in experimental animals. On the other hand, under conditions of both acute and chronic hyperglycemia, an increase, a decrease, or a normal level of blood zinc has been observed in studies conducted on humans. Thus, the objective of the investigation described here was to determine the relationship existing among zinc, glucose, and insulin under acute conditions. Thirty-six subjects of both sexes (mean age, 23 yr) were tested at 7:00 A.M. after a 12-h fast. Two antecubital veins of both forearms were punctured and maintained with physiological saline. Three experiments were performed in which zinc was administered orally, and hypertonic glucose and tolbutamid were administered intravenously. Blood samples were then collected over a period ranging from 93 to 240 min after the basal times of - 30 and 0 min. Hyperzincemia did not cause changes in plasma glucose or insulin either in the absence of or during perfusion of glucose. Hyperglycemia, hypoglycemia, and hyperinsulinemia did not modify serum zinc levels. These results demonstrate that acute zinc administration did not change carbohydrate metabolism and that sudden variations in glucose and insulin levels did not modify the serum profile of zinc.
Idioma Inglês
Data de publicação 1991-02-01
Publicado em Biological Trace Element Research. Totowa: Humana Press Inc, v. 28, n. 2, p. 123-133, 1991.
ISSN 0163-4984 (Sherpa/Romeo, fator de impacto)
Publicador Humana Press Inc
Extensão 123-133
Fonte http://dx.doi.org/10.1007/BF02863078
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1991FA53000005
Endereço permanente http://repositorio.unifesp.br/handle/11600/25190

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta