MINERALOCORTICOIDS in CONGENITAL ADRENAL-HYPERPLASIA

MINERALOCORTICOIDS in CONGENITAL ADRENAL-HYPERPLASIA

Autor Biglieri, E. G. Google Scholar
Kater, C. E. Google Scholar
Instituição UNIV CALIF SAN FRANCISCO
Universidade Federal de São Paulo (UNIFESP)
Resumo While hypertension is observed in only two of the three major subtypes of congenital adrenal hyperplasia (CAH), 11-beta- and 17-alpha-hydroxylase deficiencies, deoxycorticosterone (DOC) production is increased in all. the elevated zona fasciculata (ZF) DOC produces mineralocorticoid hypertension with suppressed renin and reduced potassium concentrations. the DOC levels in 21 -hydroxylase deficiency are in part produced by renin stimulation of the Zona glomerulosa (ZG) along with aldosterone. Assessment of the mineralocorticoid hormones of the ZF and ZF (17-deoxy steroids) provides additional unique characteristics of each subtype. Dissociation of DOC from cortisol is not unique to CAH. This dissociation is seen in other disorders and contrived conditions. There is a strong suggestion of a non-ACTH regulator of 17-deoxy steroids (DOC) that may contribute significantly to DOC production in general and effect DOC levels in CAH.
Idioma Inglês
Data de publicação 1991-01-01
Publicado em Journal of Steroid Biochemistry and Molecular Biology. Oxford: Pergamon-Elsevier B.V., v. 40, n. 4-6, p. 493-499, 1991.
ISSN 0960-0760 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 493-499
Fonte http://dx.doi.org/10.1016/0960-0760(91)90268-A
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1991GT37900002
Endereço permanente http://repositorio.unifesp.br/handle/11600/25186

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