RELEASE of CONTRACTILE AGENTS FROM RAT VAS-DEFERENS BY CLONIDINE

RELEASE of CONTRACTILE AGENTS FROM RAT VAS-DEFERENS BY CLONIDINE

Autor Jurkiewicz, N. H. Google Scholar
Jurkiewicz, A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Clonidine induces contractile effects on the isolated rat vas deferens, but not on rat uterus or guinea-pig ileum. However, we have observed that if clonidine is incubated for about 10 min with a nutrient solution containing an isolated rat vas deferens, the resulting solution can contract an isolated rat uterus, or guinea-pig ileum indicating the involvement of a substance released from the vas. This contractile effect was partially reduced by naloxone and by serotonin antagonists, and by using a denervated vas, indicating that opioids, serotonin and eventually other substances released from nerve tissue of the vas can be involved.
Idioma Inglês
Data de publicação 1991-01-01
Publicado em Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 49, n. 22, p. 1643-1649, 1991.
ISSN 0024-3205 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 1643-1649
Fonte http://dx.doi.org/10.1016/0024-3205(91)90059-K
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1991GL89600008
Endereço permanente http://repositorio.unifesp.br/handle/11600/25182

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