DECREASED SUSCEPTIBILITY TO SEIZURES INDUCED BY BICUCULLINE AFTER TRANSIENT BILATERAL CLAMPING of the CAROTID ARTERIES in RATS

DECREASED SUSCEPTIBILITY TO SEIZURES INDUCED BY BICUCULLINE AFTER TRANSIENT BILATERAL CLAMPING of the CAROTID ARTERIES in RATS

Autor Sieklucka, M. Google Scholar
Bortolotto, Z. Google Scholar
Heim, C. Google Scholar
Block, F. Google Scholar
Sontag, K. H. Google Scholar
Instituição UNIV GOTTINGEN
MAX PLANCK INST EXPTL MED
INST CLIN PATHOL
Universidade Federal de São Paulo (UNIFESP)
Resumo Rats were exposed for 24 min to bilateral clamping of the common carotid arteries (BCCA) in pentobarbital anaesthesia. 14 days later the animals were subjected to subcutaneous injection of (+)-bicuculline (3 or 4 mg/kg). A significantly decreased susceptibility to bicuculline-induced seizures could be observed in BCCA treated rats compared with sham operated controls. It is suggested that BCCA treatment protects animals against status epilepticus and lethal toxicity produced by bicuculline. Electrographic recordings of the BCCA animals revealed no ictal activity within 1 h after bicuculline injection. An analysis of the GABA content showed a significant increase in the hippocampus (HPC), frontal cortex (FCX), parietal cortex and substantia nigra in BCCA animals compared with controls. It is therefore possible that an increase in GABA content postsynaptically counteracts the GABA(A) antagonistic effect of bicuculline in BCCA animals thus preventing the normal seizure inducing effect of this substance.
Palavra-chave SEIZURE
STATUS EPILEPTICUS
BICUCULLINE
GABA
CEREBRAL PROTECTION
CAROTID OCCLUSION
Idioma Inglês
Data de publicação 1991-01-01
Publicado em Journal of Neural Transmission-general Section. Vienna: Springer-verlag Wien, v. 83, n. 1-2, p. 127-137, 1991.
ISSN 0300-9564 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 127-137
Fonte http://dx.doi.org/10.1007/BF01244459
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1991ER30900013
Endereço permanente http://repositorio.unifesp.br/handle/11600/25180

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