PARADOXICAL ANTICONVULSANT ACTIVITY of the GAMMA-AMINOBUTYRATE ANTAGONIST BICUCULLINE METHIODIDE in the RAT STRIATUM

PARADOXICAL ANTICONVULSANT ACTIVITY of the GAMMA-AMINOBUTYRATE ANTAGONIST BICUCULLINE METHIODIDE in the RAT STRIATUM

Autor Turski, L. Google Scholar
Diedrichs, S. Google Scholar
Klockgether, T. Google Scholar
Schwarz, M. Google Scholar
Turski, W. A. Google Scholar
Sontag, K. H. Google Scholar
Bortolotto, Z. A. Google Scholar
Calderazzofilho, L. S. Google Scholar
Cavalheiro, E. A. Google Scholar
Instituição MAX PLANCK INST EXPTL MED
Universidade Federal de São Paulo (UNIFESP)
Resumo Bicuculline methiodide (BMI), a gamma-aminobutyrate (GABA) antagonist, is a powerful convulsant agent when injected into the cerebral ventricles, amygdala, hippocampus, thalamus, neocortex, and deep prepiriform cortex in rats. in contrast, bilateral microinjection of BMI into the rat striatum confers protection against seizures induced by the cholinergic agonist pilocarpine (380 mg/kg, i.p.), with an ED50 of 94 fmol (range 45-195 fmol). No topographical variation in the anticonvulsant action of BMI was detected throughout rostrocaudal and dorsoventral aspects of the striatum. the anticonvulsant action of BMI in the striatum was reversed by coadministration of the GABA agonist muscimol or by blocking GABA-mediated inhibition in either the substantia nigra pars reticulata or in the entopeduncular nucleus. the results show that blockade of GABA-mediated inhibition in the striatum has a powerful anticonvulsant effect in the pilocarpine model, suggesting that GABAergic transmission in the striatum modulates the seizure propagation in the forebrain.
Palavra-chave PILOCARPINE
SEIZURE
EPILEPSY
BRAIN DAMAGE
BASAL GANGLIA
Idioma Inglês
Data de publicação 1991-01-01
Publicado em Synapse. New York: Wiley-liss, v. 7, n. 1, p. 14-20, 1991.
ISSN 0887-4476 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 14-20
Fonte http://dx.doi.org/10.1002/syn.890070103
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1991ER65500002
Endereço permanente http://repositorio.unifesp.br/handle/11600/25178

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