Reversal of left ventricular hypertrophy following treatment of hypertension with isradipine

Reversal of left ventricular hypertrophy following treatment of hypertension with isradipine

Autor Saragoca, Manoel A. Autor UNIFESP Google Scholar
Portela, Jorge E. Autor UNIFESP Google Scholar
Abreu, Patrícia Google Scholar
Plavnik, Frida Liane Autor UNIFESP Google Scholar
Ventura, Rita Autor UNIFESP Google Scholar
Vanneta, Adália Autor UNIFESP Google Scholar
Ajzen, Horacio Autor UNIFESP Google Scholar
Ramos, Oswaldo L. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo In order to complement earlier short-term observations, we studied the effects of isradipine (1.25 or 2.5 mg twice daily) on blood pressure as well as its action in reversing cardiac hypertrophy in 25 moderately hypertensive patients. We observed that the treatment produced short-term (3 month) and longer-term (9 month) control of blood pressure [decreases in mean arterial pressure (MAP) from 128 +/- 2.3 to 112 +/- 2.7 mm Hg and to 105.5 +/- 2.9 mm Hg; p < 0.001] while heart rate remained constant throughout the study (from 76.6 +/- 2.3 to 74.7 +/- 2.4 beats/min; NS). Reversal of left ventricular hypertrophy (LVH) obtained after 3 months of treatment (LV mass index from 173.7 +/- 8.8 to 135.7 +/-4.5 g/m2; p < 0.001) was accentuated with continued therapy (to 131.0 +/- 4.0 and 124.4 +/- 3.1 g/m2 at 6 and 9 months, respectively; p < 0.01). These results indicate that significant regression of LVH can be obtained with short-term treatment of hypertension with isradipine and that this effect will be fully obtained with longer-term (9 month) therapy.
Idioma Inglês
Data 1991-01-01
Publicado em Journal of Cardiovascular Pharmacology. Philadelphia: Lippincott-raven Publ, v. 18, p. S28-S30, 1991.
ISSN 0160-2446 (Sherpa/Romeo, fator de impacto)
Editor Lippincott-raven Publ
Extensão S28-S30
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:A1991GN58200009

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