A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat

A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat

Author Bonilha, Andre.Mateis Martins Autor UNIFESP Google Scholar
Saraiva, Roberto Magalhães Autor UNIFESP Google Scholar
Kanashiro-Takeuchi, Rosimeire Miyuki Autor UNIFESP Google Scholar
Portes, Leslie Andrews Autor UNIFESP Google Scholar
Antonio, Ednei Luiz Autor UNIFESP Google Scholar
Tucci, Paulo José Ferreira Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Nine lead electrocardiograms of non-infarcted (N = 61) and infarcted (N = 71) female Wistar rats (200-250 g) were analyzed in order to distinguish left ventricle myocardial infarction (MI) larger than 40% (LMI) from MI smaller than 40% (SMI). MI larger than 40% clearly caused a deviation of ÂQRS and ÂT from normal values of 270-360 degrees to 90-270 degrees. Infarcted rats showed Q wave in D1 larger than 1 mm with 94% sensitivity and 100% specificity. The sum of QRS positivity in V1, V2 and V6 lower than 10 mm identified MI with 82% sensitivity and 100% specificity. The data showed that MI can be easily and reliably diagnosed by electrocardiogram in the rat. However, contradicting what is frequently believed, when specificity and sensitivity were analyzed focusing on MI size, none of these current electrocardiographic indices of MI size adequately discriminates LMI from SMI.
Keywords Myocardial infarction size
Rats
Electrocardiogram
Echocardiogram
ROC curve
Language English
Date 2005-04-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 4, p. 615-619, 2005.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 615-619
Origin http://dx.doi.org/10.1590/S0100-879X2005000400016
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000228962700016
SciELO ID S0100-879X2005000400016 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/2465

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