Effect of an isotonic rehydration sports drink and exercise on urolithiasis in rats

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dc.contributor.author Abreu, Nayda Parisio de [UNIFESP]
dc.contributor.author Bergamaschi, Cassia Toledo [UNIFESP]
dc.contributor.author Di Marco, Giovana Seno [UNIFESP]
dc.contributor.author Razvickas, Clara Versolato [UNIFESP]
dc.contributor.author Schor, Nestor [UNIFESP]
dc.date.accessioned 2015-06-14T13:31:30Z
dc.date.available 2015-06-14T13:31:30Z
dc.date.issued 2005-04-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2005000400011
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 4, p. 577-582, 2005.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/2457
dc.description.abstract The objective of the present study was to evaluate the role of physical exercise as well as the influence of hydration with an isotonic sports drink on renal function in male Wistar rats. Four groups were studied over a period of 42 days: 1) control (N = 9); 2) physical exercise (Exe, N = 7); 3) isotonic drink (Drink, N = 8); 4) physical exercise + isotonic drink (Exe + Drink, N = 8). Physical exercise consisted of running on a motor-driven treadmill for 1 h/day, at 20 m/min, 5 days a week. The isotonic sports drink was a commercial solution used by athletes for rehydration after physical activity, 2 ml administered by gavage twice a day. Urine cultures were performed in all animals. Twenty-four-hour urine samples were collected in metabolic cages at the beginning and at the end of the protocol period. Urinary and plasma parameters (sodium, potassium, urea, creatinine, calcium) did not differ among groups. However, an amorphous material was observed in the bladders of animals in the Exe + Drink and Drink groups. Characterization of the material by Western blot revealed the presence of Tamm-Horsfall protein and angiotensin converting enzyme. Physical exercise and the isotonic drink did not change the plasma or urinary parameters measured. However, the isotonic drink induced the formation of intravesical matrix, suggesting a potential lithogenic risk. en
dc.format.extent 577-582
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Renal function en
dc.subject Isotonic rehydration sports drink en
dc.subject Physical activity en
dc.subject Renal stone en
dc.subject Nephrolithiasis en
dc.subject Tamm-Horsfall protein en
dc.title Effect of an isotonic rehydration sports drink and exercise on urolithiasis in rats en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Departamento de Medicina Disciplina de Nefrologia
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Departamento de Farmacologia Disciplina de Fisiologia Cardiovascular e Respiratória
dc.description.affiliationUnifesp UNIFESP, Depto. de Medicina Disciplina de Nefrologia
dc.description.affiliationUnifesp UNIFESP, Depto. de Farmacologia Disciplina de Fisiologia Cardiovascular e Respiratória
dc.identifier.file S0100-879X2005000400011.pdf
dc.identifier.scielo S0100-879X2005000400011
dc.identifier.doi 10.1590/S0100-879X2005000400011
dc.description.source SciELO
dc.identifier.wos WOS:000228962700011



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