Effect of an isotonic rehydration sports drink and exercise on urolithiasis in rats

Effect of an isotonic rehydration sports drink and exercise on urolithiasis in rats

Autor Abreu, Nayda Parisio de Autor UNIFESP Google Scholar
Bergamaschi, Cassia Toledo Autor UNIFESP Google Scholar
Di Marco, Giovana Seno Autor UNIFESP Google Scholar
Razvickas, Clara Versolato Autor UNIFESP Google Scholar
Schor, Nestor Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The objective of the present study was to evaluate the role of physical exercise as well as the influence of hydration with an isotonic sports drink on renal function in male Wistar rats. Four groups were studied over a period of 42 days: 1) control (N = 9); 2) physical exercise (Exe, N = 7); 3) isotonic drink (Drink, N = 8); 4) physical exercise + isotonic drink (Exe + Drink, N = 8). Physical exercise consisted of running on a motor-driven treadmill for 1 h/day, at 20 m/min, 5 days a week. The isotonic sports drink was a commercial solution used by athletes for rehydration after physical activity, 2 ml administered by gavage twice a day. Urine cultures were performed in all animals. Twenty-four-hour urine samples were collected in metabolic cages at the beginning and at the end of the protocol period. Urinary and plasma parameters (sodium, potassium, urea, creatinine, calcium) did not differ among groups. However, an amorphous material was observed in the bladders of animals in the Exe + Drink and Drink groups. Characterization of the material by Western blot revealed the presence of Tamm-Horsfall protein and angiotensin converting enzyme. Physical exercise and the isotonic drink did not change the plasma or urinary parameters measured. However, the isotonic drink induced the formation of intravesical matrix, suggesting a potential lithogenic risk.
Palavra-chave Renal function
Isotonic rehydration sports drink
Physical activity
Renal stone
Nephrolithiasis
Tamm-Horsfall protein
Idioma Inglês
Data de publicação 2005-04-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 4, p. 577-582, 2005.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 577-582
Fonte http://dx.doi.org/10.1590/S0100-879X2005000400011
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000228962700011
SciELO S0100-879X2005000400011 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/2457

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