Reduced schedule of human anti rabies immunization with Fuenzalida & Palacios vaccine

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dc.contributor.author Zanetti, Carlos Roberto [UNIFESP]
dc.contributor.author Favoretto, Silvana Regina
dc.contributor.author Tino, Milene Silva [UNIFESP]
dc.contributor.author Albas, Avelino
dc.contributor.author Valentini, Elizabeth Juliana Ghiuro
dc.contributor.author Pereira, Octávio Augusto de Carvalho [UNIFESP]
dc.date.accessioned 2015-06-14T13:24:18Z
dc.date.available 2015-06-14T13:24:18Z
dc.date.issued 1989-02-01
dc.identifier http://dx.doi.org/10.1590/S0036-46651989000100005
dc.identifier.citation ZANETTI, Carlos Roberto et al . Reduced schedule of human anti rabies immunization with Fuenzalida & Palacios vaccine. Rev. Inst. Med. trop. S. Paulo, São Paulo , v. 31, n. 1, p. 23-27, fev. 1989
dc.identifier.issn 0036-4665
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/240
dc.description.abstract The present study evaluates the humoral and cellular immune responses in 35 volunteers submited to short antirabies vaccination schedules with the Fuenzalida & Palacios vaccine based on the administration of doses on non consecutive days. The volunteers were divided into two groups. The first group received a total number of five doses given on days 0, 4, 7, 20 and 35. The other group received four doses, the first one being a double dose given on day 0 and than three other single doses on days 7, 20 and 35. The evaluation of humoral immune response was carried out by serum neutralization (SN) and indirect immunofluorescense (IIF) tests, while the cellular immune response was evaluated by lymphoblastic transformation assay (LTA) and skin test (ST). According to our results these reduced schedules elicited early and effective humoral and cellulafimmune responses to rabies antigen suggesting that new reduced schedules should be extensively studied in order to give the proper bases to the proposition of changes in the current long-term schedule. en
dc.description.abstract O objetivo do presente trabalho foi estudar um novo esquema de vacinação anti-rábica humana, com um menor número de doses, administradas em dias não consecutivos (5 doses nos dias 0, 4, 7, 20 e 35). A avaliação da resposta imune humoral foi feita pela prova de soroneutralização e pela reação de imunofluorescência indireta, enquanto que a resposta imune celular foi avaliada pela transformação linfoblástica em cultura de sangue total e pelo teste cutâneo de leitura tardia. Foram estudados um total de 35 voluntários, submetidos ao esquema reduzido de vacinação, e os resultados encontrados permitem afirmar que, embora o número de casos seja relativamente pequeno, este novo esquema de vacinação mostrou-se capaz de induzir a produção de imunoglobulinas anti-rábicas, bem como de eli-citar a resposta imune celular ao antígeno rábico. pt
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 23-27
dc.language.iso eng
dc.publisher Instituto de Medicina Tropical
dc.relation.ispartof Revista do Instituto de Medicina Tropical de São Paulo
dc.rights Acesso aberto
dc.subject Antirabies vaccination en
dc.subject Reduced schedule en
dc.subject Cellular immunity en
dc.title Reduced schedule of human anti rabies immunization with Fuenzalida & Palacios vaccine en
dc.title.alternative Esquema reduzido de vacinação anti-rábica humana pt
dc.type Artigo
dc.contributor.institution Instituto Pasteur de São Paulo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Instituto Butantan
dc.description.affiliation Instituto Pasteur de São Paulo
dc.description.affiliation Escola Paulista de Medicina
dc.description.affiliation Instituto Butantan
dc.description.affiliationUnifesp UNIFESP, EPM
dc.identifier.file S0036-46651989000100005.pdf
dc.identifier.scielo S0036-46651989000100005
dc.identifier.doi 10.1590/S0036-46651989000100005
dc.description.source SciELO
dc.identifier.wos WOS:A1989U113800005



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