Reduced schedule of human anti rabies immunization with Fuenzalida & Palacios vaccine

Reduced schedule of human anti rabies immunization with Fuenzalida & Palacios vaccine

Alternative title Esquema reduzido de vacinação anti-rábica humana
Author Zanetti, Carlos Roberto Autor UNIFESP Google Scholar
Favoretto, Silvana Regina Google Scholar
Tino, Milene Silva Autor UNIFESP Google Scholar
Albas, Avelino Google Scholar
Valentini, Elizabeth Juliana Ghiuro Google Scholar
Pereira, Octávio Augusto de Carvalho Autor UNIFESP Google Scholar
Institution Instituto Pasteur de São Paulo
Universidade Federal de São Paulo (UNIFESP)
Instituto Butantan
Abstract The present study evaluates the humoral and cellular immune responses in 35 volunteers submited to short antirabies vaccination schedules with the Fuenzalida & Palacios vaccine based on the administration of doses on non consecutive days. The volunteers were divided into two groups. The first group received a total number of five doses given on days 0, 4, 7, 20 and 35. The other group received four doses, the first one being a double dose given on day 0 and than three other single doses on days 7, 20 and 35. The evaluation of humoral immune response was carried out by serum neutralization (SN) and indirect immunofluorescense (IIF) tests, while the cellular immune response was evaluated by lymphoblastic transformation assay (LTA) and skin test (ST). According to our results these reduced schedules elicited early and effective humoral and cellulafimmune responses to rabies antigen suggesting that new reduced schedules should be extensively studied in order to give the proper bases to the proposition of changes in the current long-term schedule.

O objetivo do presente trabalho foi estudar um novo esquema de vacinação anti-rábica humana, com um menor número de doses, administradas em dias não consecutivos (5 doses nos dias 0, 4, 7, 20 e 35). A avaliação da resposta imune humoral foi feita pela prova de soroneutralização e pela reação de imunofluorescência indireta, enquanto que a resposta imune celular foi avaliada pela transformação linfoblástica em cultura de sangue total e pelo teste cutâneo de leitura tardia. Foram estudados um total de 35 voluntários, submetidos ao esquema reduzido de vacinação, e os resultados encontrados permitem afirmar que, embora o número de casos seja relativamente pequeno, este novo esquema de vacinação mostrou-se capaz de induzir a produção de imunoglobulinas anti-rábicas, bem como de eli-citar a resposta imune celular ao antígeno rábico.
Keywords Antirabies vaccination
Reduced schedule
Cellular immunity
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 1989-02-01
Published in ZANETTI, Carlos Roberto et al . Reduced schedule of human anti rabies immunization with Fuenzalida & Palacios vaccine. Rev. Inst. Med. trop. S. Paulo, São Paulo , v. 31, n. 1, p. 23-27, fev. 1989
ISSN 0036-4665 (Sherpa/Romeo, impact factor)
Publisher Instituto de Medicina Tropical
Extent 23-27
Origin http://dx.doi.org/10.1590/S0036-46651989000100005
Access rights Open access Open Access
Type Article
Web of Science ID WOS:A1989U113800005
SciELO ID S0036-46651989000100005 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/240

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