Sarcomatoid differentiation in renal cell carcinoma: prognostic implications

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dc.contributor.author Dall'Oglio, Marcos Francisco [UNIFESP]
dc.contributor.author Lieberknecht, Marco [UNIFESP]
dc.contributor.author Gouveia, Valter [UNIFESP]
dc.contributor.author Sant'anna, Alexandre C. [UNIFESP]
dc.contributor.author Leite, Kátia Ramos Moreira [UNIFESP]
dc.contributor.author Srougi, Miguel [UNIFESP]
dc.date.accessioned 2015-06-14T13:31:26Z
dc.date.available 2015-06-14T13:31:26Z
dc.date.issued 2005-02-01
dc.identifier http://dx.doi.org/10.1590/S1677-55382005000100003
dc.identifier.citation International braz j urol. Sociedade Brasileira de Urologia, v. 31, n. 1, p. 10-16, 2005.
dc.identifier.issn 1677-5538
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/2395
dc.description.abstract INTRODUCTION: Renal cell carcinoma with sarcomatoid differentiation is a tumor with aggressive behavior that is poorly responsive to immunotherapy. The objective of this study is to report our experience in the treatment of 15 patients with this tumor. MATERIALS AND METHODS: We retrospectively analyzed 15 consecutive cases of renal cell carcinoma with sarcomatoid differentiation diagnosed between 1991 and 2003. The clinical presentation and the pathological stage were assessed, as were the tumor's pathological features, use of adjuvant immunotherapy and survival. The study's primary end-point was to assess survival of these individuals. RESULTS: The sample included 8 women and 7 men with mean age of 63 years (44 - 80); follow-up ranged from 1 to 100 months (mean 34). Upon presentation, 87% were symptomatic and 4 individuals had metastatic disease. Mean tumor size was 9.5 cm (4 - 24) with the following pathological stages: 7% pT1, 7% pT2, 33% pT3, and 53% pT4. The pathological features showed high-grade tumors with tumoral necrosis in 87% of the lesions and 80% of intratumoral microvascular invasion. Disease-free and cancer-specific survival rates were 40 and 46% respectively, with 2 cases responding to adjuvant immunotherapy. CONCLUSIONS: Patients with sarcomatoid tumors of the kidney have a low life expectancy, and sometimes surgical resection associated with immunotherapy can lead to a long-lasting therapeutic response. en
dc.format.extent 10-16
dc.language.iso eng
dc.publisher Sociedade Brasileira de Urologia
dc.relation.ispartof International braz j urol
dc.rights Acesso aberto
dc.subject kidney neoplasms en
dc.subject carcinoma en
dc.subject renal cell en
dc.subject neoplasms metastasis en
dc.title Sarcomatoid differentiation in renal cell carcinoma: prognostic implications en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Division of Urology
dc.description.affiliationUnifesp UNIFESP, EPM, Division of Urology
dc.identifier.file S1677-55382005000100003.pdf
dc.identifier.scielo S1677-55382005000100003
dc.identifier.doi 10.1590/S1677-55382005000100003
dc.description.source SciELO



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