Establishment of the serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy in the city of São Paulo, Brazil

Establishment of the serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy in the city of São Paulo, Brazil

Autor Kallas, Esper Georges Autor UNIFESP Google Scholar
Bassichetto, Katia Cristina Google Scholar
Oliveira, Solange Maria Google Scholar
Goldenberg, Ieda Google Scholar
Bortoloto, Reginaldo Google Scholar
Moreno, Diva Maria Faleiros C. Google Scholar
Kanashiro, Cecilia Google Scholar
Sauer, Mariana Melillo Autor UNIFESP Google Scholar
Sucupira, Maria Cecília Araripe Autor UNIFESP Google Scholar
Diniz, Aparecido Autor UNIFESP Google Scholar
Mesquita, Fabio C. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Public Health Department of São Paulo
Henfil Counseling Testing Center
Specialized Attending Service in STD/Aids Campos Elíseos
Prevention and Attendance Center in STD/Aids Lapa
Pirituba Counseling Testing Center
Lapa City Central Laboratory
Resumo Several strategies aim at characterizing the AIDS epidemic in different parts of the world. Among these, the identification of recent HIV-1 infections using the recently described serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy was employed in four testing sites of the City of São Paulo Public Health Department (CSPPHD). Those identified as recently infected were invited to participate in a prospective clinical and laboratory evaluation study. We describe the establishment of the patient identification network and the success in enrolling the participants, as well as their clinical and laboratory characteristics. From May to December 2002, 6,443 persons were tested for HIV in the four participating sites, of whom 384 (5.96%) tested HIV-1 positive; 43 (11.2%) of them were identified as recently infected. Twenty-two were successfully enrolled in the follow-up study, but three of them did not meet clinical and/or laboratory criteria for recent HIV-1 infection. After these exclusions, the laboratory findings revealed a median CD4+ T lymphocyte count of 585 cells/muL (inter-quartile range 25-75% [IQR], 372-754), a CD8+ T lymphocyte count of 886 cells/muL (IQR, 553-1098), a viral load of 11,000 HIV-RNA copies/mL (IQR, 3,650-78,150), log10 of 4.04 (IQR 3.56-4.88). The identification of recent HIV infections is an extremely valuable way to evaluate the spread of the virus in a given population, especially when cohort studies, considered the gold standard method to evaluate incidence, are not available. This work demonstrated that establishing a network to identify such patients is a feasible task, even considering the difficulties in a large, resource-limited country or city.
Palavra-chave HIV
recent infection
network
São Paulo
Idioma Inglês
Data de publicação 2004-12-01
Publicado em Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 8, n. 6, p. 399-406, 2004.
ISSN 1413-8670 (Sherpa/Romeo)
Publicador Brazilian Society of Infectious Diseases
Extensão 399-406
Fonte http://dx.doi.org/10.1590/S1413-86702004000600003
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1413-86702004000600003 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/2311

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