Morphological and functional alterations of the intestine of rats with iron-deficiency anemia

Morphological and functional alterations of the intestine of rats with iron-deficiency anemia

Autor Wayhs, Mônica Lisboa Chang Autor UNIFESP Google Scholar
Patricio, Francy Reis da Silva Autor UNIFESP Google Scholar
Amancio, Olga Maria Silverio Autor UNIFESP Google Scholar
Pedroso, Margareth Zabeu Autor UNIFESP Google Scholar
Fagundes Neto, Ulysses Autor UNIFESP Google Scholar
Morais, Mauro Batista de Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The present study was designed to assess the intestinal absorption of D-xylose and jejunal morphometry in rats with iron-deficiency anemia. Male Wistar rats were randomly divided into a control group (diet containing 50 mg Fe/kg, N = 12) and an anemic group (diet containing <5 mg Fe/kg, N = 12). The animals were housed in individual metabolic cages and deionized water and diet were provided ad libitum for 6 weeks. Hemoglobin and hematocrit were determined at 0, 2, 4, and 6 weeks. At the end of the study the rats were submitted to a D-xylose absorption test (50 mg/100 g body weight) and sacrificed and a jejunal specimen was obtained for morphometric study. At the end of the study the hemoglobin and hematocrit of the anemic rats (8.7 ± 0.9 g/dl and 34.1 ± 2.9%, respectively) were significantly (P < 0.05) lower than those of the controls (13.9 ± 1.4 g/dl and 47.1 ± 1.5%, respectively). There was no statistical difference in D-xylose absorption between the anemic (46.5 ± 7.4%) and control (43.4 ± 9.0%) groups. The anemic animals presented statistically greater villus height (445.3 ± 36.8 µm), mucosal thickness (614.3 ± 56.3 µm) and epithelial surface (5063.0 ± 658.6 µm) than control (371.8 ± 34.3, 526.7 ± 62.3 and 4401.2 ± 704.4 µm, respectively; P < 0.05). The increase in jejunum villus height, mucosal thickness and epithelial surface in rats with iron-deficiency anemia suggests a compensatory intestinal mechanism to increase intestinal iron absorption.
Palavra-chave Iron deficiency
Anemia
Jejunal villus height
Jejunal mucosal thickness
Jejunal epithelial surface
Idioma Inglês
Data de publicação 2004-11-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 11, p. 1631-1635, 2004.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 1631-1635
Fonte http://dx.doi.org/10.1590/S0100-879X2004001100006
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000225128700006
SciELO S0100-879X2004001100006 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/2272

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