Demographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil

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dc.contributor.author Focaccia, R.
dc.contributor.author Baraldo, D.c.m.
dc.contributor.author Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
dc.contributor.author Martinelli, A.l.c.
dc.contributor.author Carrilho, F.j.
dc.contributor.author Gonçales Junior, Fernando Lopes
dc.contributor.author Pedroso, M.l.a.
dc.contributor.author Coelho, H.s.m.
dc.contributor.author Lacerda, M.a.
dc.contributor.author Brandão, C.e.
dc.contributor.author Mattos, A.a.
dc.contributor.author Lira, L.g.c.
dc.contributor.author Zamin Jr., I.
dc.contributor.author Pinheiro, J.o.p.
dc.contributor.author Tovo, C.v.
dc.contributor.author Both, C.t.
dc.contributor.author Soares, J.a.s.
dc.contributor.author Dittrich, S.
dc.date.accessioned 2015-06-14T13:31:17Z
dc.date.available 2015-06-14T13:31:17Z
dc.date.issued 2004-10-01
dc.identifier http://dx.doi.org/10.1590/S1413-86702004000500003
dc.identifier.citation Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 8, n. 5, p. 348-355, 2004.
dc.identifier.issn 1413-8670
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/2231
dc.description.abstract Hepatitis C virus (HCV) infection is a serious public health problem, since 80% to 85% of HCV carriers develop a persistent infection that can progress into liver cirrhosis and hepatocarcinoma. Considering that the response of hepatitis C patients to combination therapy with interferon and ribavirin depends on HCV characteristics as well as on host features, we made a retrospective analysis of demographic and anthropometrical data and HCV genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil. The medical records of 4,996 patients were reviewed, 81% from public and 19% from private institutions. Patients' median age was 46 years, and there was a higher prevalence of male (62%) and white patients (80%). The analysis of HCV-infecting strains showed a predominance of genotype 1 (64%) over genotypes 2 and 3. The patients' mean weight was 70.6 kg, and 65% of the patients weighed less than 77kg. Overweight and obesity were observed in 37.8% and 13.6% of the patients, respectively. Since a body weight of 75 kg or less has been considered an independent factor that significantly increases the odds of achieving a sustained virological response, the Brazilian population seems to have a more favorable body weight profile to achieve a sustained response than the American and European populations. The finding that 65% of chronic hepatitis C patients have a body weight of 77 kg or less may have a positive pharmacoeconomic impact on the treatment of genotype 1 HCV patients with weight-based doses of peginterferon. en
dc.format.extent 348-355
dc.language.iso eng
dc.publisher Brazilian Society of Infectious Diseases
dc.relation.ispartof Brazilian Journal of Infectious Diseases
dc.rights Acesso aberto
dc.subject HCV en
dc.subject chronic hepatitis C en
dc.subject genotype en
dc.subject body weight en
dc.subject Brazil en
dc.title Demographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil en
dc.type Artigo
dc.contributor.institution Emílio Ribas Institute
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution São Paulo University Medical School of Ribeirão Preto
dc.contributor.institution São Paulo University School of Medicine
dc.contributor.institution Universidade Estadual de Campinas (UNICAMP)
dc.contributor.institution Federal University of Paraná
dc.contributor.institution Secretary of State of Paraná CRE Metropolitan
dc.contributor.institution Federal University of Rio de Janeiro
dc.contributor.institution Private Institution
dc.contributor.institution UNIRIO Graffée Guinle Universitary Hospital
dc.contributor.institution Santa Casa de Misericórdia Gastroenterology Service
dc.contributor.institution Federal University of Bahia
dc.description.affiliation Emílio Ribas Institute
dc.description.affiliation Federal University of São Paulo
dc.description.affiliation São Paulo University Medical School of Ribeirão Preto
dc.description.affiliation São Paulo University School of Medicine
dc.description.affiliation University of Campinas Medical Sciences Faculty
dc.description.affiliation Federal University of Paraná
dc.description.affiliation Secretary of State of Paraná CRE Metropolitan
dc.description.affiliation Federal University of Rio de Janeiro
dc.description.affiliation Private Institution
dc.description.affiliation UNIRIO Graffée Guinle Universitary Hospital
dc.description.affiliation Santa Casa de Misericórdia Gastroenterology Service
dc.description.affiliation Federal University of Bahia
dc.description.affiliationUnifesp UNIFESP
dc.identifier.file S1413-86702004000500003.pdf
dc.identifier.scielo S1413-86702004000500003
dc.identifier.doi 10.1590/S1413-86702004000500003
dc.description.source SciELO



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