Demographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil

Demographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil

Author Focaccia, R. Google Scholar
Baraldo, D.c.m. Google Scholar
Ferraz, Maria Lucia Cardoso Gomes Autor UNIFESP Google Scholar
Martinelli, A.l.c. Google Scholar
Carrilho, F.j. Google Scholar
Gonçales Junior, Fernando Lopes Google Scholar
Pedroso, M.l.a. Google Scholar
Coelho, H.s.m. Google Scholar
Lacerda, M.a. Google Scholar
Brandão, C.e. Google Scholar
Mattos, A.a. Google Scholar
Lira, L.g.c. Google Scholar
Zamin Jr., I. Google Scholar
Pinheiro, J.o.p. Google Scholar
Tovo, C.v. Google Scholar
Both, C.t. Google Scholar
Soares, J.a.s. Google Scholar
Dittrich, S. Google Scholar
Institution Emílio Ribas Institute
Universidade Federal de São Paulo (UNIFESP)
São Paulo University Medical School of Ribeirão Preto
São Paulo University School of Medicine
Universidade Estadual de Campinas (UNICAMP)
Federal University of Paraná
Secretary of State of Paraná CRE Metropolitan
Federal University of Rio de Janeiro
Private Institution
UNIRIO Graffée Guinle Universitary Hospital
Santa Casa de Misericórdia Gastroenterology Service
Federal University of Bahia
Abstract Hepatitis C virus (HCV) infection is a serious public health problem, since 80% to 85% of HCV carriers develop a persistent infection that can progress into liver cirrhosis and hepatocarcinoma. Considering that the response of hepatitis C patients to combination therapy with interferon and ribavirin depends on HCV characteristics as well as on host features, we made a retrospective analysis of demographic and anthropometrical data and HCV genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil. The medical records of 4,996 patients were reviewed, 81% from public and 19% from private institutions. Patients' median age was 46 years, and there was a higher prevalence of male (62%) and white patients (80%). The analysis of HCV-infecting strains showed a predominance of genotype 1 (64%) over genotypes 2 and 3. The patients' mean weight was 70.6 kg, and 65% of the patients weighed less than 77kg. Overweight and obesity were observed in 37.8% and 13.6% of the patients, respectively. Since a body weight of 75 kg or less has been considered an independent factor that significantly increases the odds of achieving a sustained virological response, the Brazilian population seems to have a more favorable body weight profile to achieve a sustained response than the American and European populations. The finding that 65% of chronic hepatitis C patients have a body weight of 77 kg or less may have a positive pharmacoeconomic impact on the treatment of genotype 1 HCV patients with weight-based doses of peginterferon.
Keywords HCV
chronic hepatitis C
genotype
body weight
Brazil
Language English
Date 2004-10-01
Published in Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 8, n. 5, p. 348-355, 2004.
ISSN 1413-8670 (Sherpa/Romeo)
Publisher Brazilian Society of Infectious Diseases
Extent 348-355
Origin http://dx.doi.org/10.1590/S1413-86702004000500003
Access rights Open access Open Access
Type Article
SciELO ID S1413-86702004000500003 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/2231

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