Correlation between serum E-selectin levels and panoramic nailfold capillaroscopy in systemic sclerosis

Correlation between serum E-selectin levels and panoramic nailfold capillaroscopy in systemic sclerosis

Author Valim, Valeria Autor UNIFESP Google Scholar
Assis, L.s.s. Autor UNIFESP Google Scholar
Autor UNIFESP Google Scholar
Trevisani, Virgínia Fernandes Moça Autor UNIFESP Google Scholar
Pucinelli, Mário Luis Cardoso Autor UNIFESP Google Scholar
Andrade, Luiz Eduardo Coelho Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract E-selectin is expressed by the activated endothelium and its plasma levels are increased in patients with systemic sclerosis. Eighteen patients fulfilling the American Rheumatism Association criteria for systemic sclerosis, 15 females and 3 males, 42-70 years old, 9 with diffuse and 9 with limited forms, were sequentially recruited for this study. Serum E-selectin levels were determined by commercially available ELISA and their association with nailfold capillaroscopic abnormalities was investigated. Nailfold capillaries were analyzed by 16X magnification wide-field capillaroscopy. Two parameters on capillaroscopy were used to correlate to serum E-selectin: deletion and ectasia. Data were analyzed statistically by the Student t-test and Spearman correlation. Two-tailed P values below 0.05 were considered significant. E-selectin range was 38 to 200 ng/ml (80 ± 39.94). There was a correlation between serum E-selectin levels and the deletion capillaroscopic score (r = 0.50, P < 0.035). This correlation was even stronger within the first 48 months of diagnosis (r = 0.63, P < 0.048). On the other hand, no association was observed between selectin and ectasia. Patients with diffuse disease presented higher serum E-selectin levels than patients with limited disease, although the difference was not statistically significant (96.44 ± 48.04 vs 63.56 ± 21.77 ng/dl; P = 0.08). The present study is the first showing a correlation between soluble serum E-selectin levels and alterations in capillaroscopy. The stronger correlation of deletion score in capillaroscopy in early disease suggests that serum E-selectin levels might be a useful biochemical marker of disease activity in systemic sclerosis.
Keywords Systemic sclerosis
Nailfold capillaroscopy
E-selectin
Adhesion molecules
Language English
Date 2004-09-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 9, p. 1423-1427, 2004.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 1423-1427
Origin http://dx.doi.org/10.1590/S0100-879X2004000900018
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000223707100018
SciELO ID S0100-879X2004000900018 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/2215

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