Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic Forest

Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic Forest

Author Suffredini, I.b. Google Scholar
Sader, Helio Silva Autor UNIFESP Google Scholar
Gonçalves, Azizedite Guedes Google Scholar
Reis, Adriana O. Autor UNIFESP Google Scholar
Gales, Ana Cristina Autor UNIFESP Google Scholar
Varella, Antonio Drauzio Google Scholar
Younes, Riad Naim Google Scholar
Institution Universidade Paulista Laboratório de Extração
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Maranhão Centro de Ciências Biológicas e da Saúde
Abstract More than 20% of the world's biodiversity is located in Brazilian forests and only a few plant extracts have been evaluated for potential antibacterial activity. In the present study, 705 organic and aqueous extracts of plants obtained from different Amazon Rain Forest and Atlantic Forest plants were screened for antibacterial activity at 100 µg/ml, using a microdilution broth assay against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli. One extract, VO581, was active against S. aureus (minimum inhibitory concentration (MIC) = 140 µg/ml and minimal bactericidal concentration (MBC) = 160 µg/ml, organic extract obtained from stems) and two extracts were active against E. faecalis, SM053 (MIC = 80 µg/ml and MBC = 90 µg/ml, organic extract obtained from aerial parts), and MY841 (MIC = 30 µg/ml and MBC = 50 µg/ml, organic extract obtained from stems). The most active fractions are being fractionated to identify their active substances. Higher concentrations of other extracts are currently being evaluated against the same microorganisms.
Keywords Plant extract
Antibacterial activity
Screening
Amazon Rain Forest
Atlantic Forest
Language English
Date 2004-03-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 3, p. 379-384, 2004.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 379-384
Origin http://dx.doi.org/10.1590/S0100-879X2004000300015
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000220371600015
SciELO ID S0100-879X2004000300015 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/2031

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