Fatores associados à hipovitaminose D na doença renal crônica

Fatores associados à hipovitaminose D na doença renal crônica

Alternative title Factors associated with vitamin D deficiency in chronic kidney disease
Author Figuiredo-Dias, Vilani Autor UNIFESP Google Scholar
Advisor Kamimura, Maria Ayako Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Graduate program Nutrição - São Paulo
Abstract Background: Hypovitaminosis D is highly prevalent among chronic kidney disease patients and it has been associated with worse outcome even in the earlier stages of the disease. Objective: This study aimed to investigate the risk factors for hypovitaminosis D in nondialyzed chronic kidney disease patients. Design: This cross-sectional study included 120 chronic kidney disease patients on stages 2 to 5 (62% male, age 55.4±11.3yr, estimated glomerular filtration rate 35.1±15ml/min, body mass index (BMI) 27.1±5.2kg/m2, 31% diabetics). Serum 25-hydroxivitamin D was measured by chemiluminescence. Subjective global assessment, total body fat (dual-energy X-ray absorptiometry), visceral and subcutaneous abdominal fat (computed tomography) and several laboratory parameters were assessed. Results: Insufficiency of 25-hydroxivitamin D (15-30ng/ml) was observed in 55% of the patients and deficiency (<15ng/ml) in 20%. Patients with diabetes, BMI ≥30kg/m2, and who had the blood collection during the winter or spring had lower 25-hydroxivitamin D levels. Serum 25-hydroxivitamin D correlated inversely with parathyroid hormone, proteinuria, insulin resistance, leptin, and subcutaneous abdominal fat. The risk factors for hypovitaminosis D were diabetes (odds ratio 3.8; 95% CI 1.2-11.7; P=0.022) and BMI ≥30kg/m2 (odds ratio 4.3; 95% CI 1.2-15.3; P=0.018). In the logistic regression analysis adjusting for gender, skin color and season of the year, diabetes and BMI ≥30kg/m2 were independently associated with hypovitaminosis D. Conclusions: Diabetes and obesity were the risk factors for hypovitaminosis D in nondialyzed chronic kidney disease patients. Effective interventional protocols of vitamin D supplementation taking into account these risk factors are warranted for this population.
Keywords Deficiência de Vitaminas
Deficiência de Vitamina D
Diabetes Mellitus
Obesidade
Doença Crônica
Rim/patologia
Hypovitaminosis D
25-hydroxivitamin D
Diabetes
Obesity
Chronic kidney disease.
Language Portuguese
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundação Oswaldo Ramos
Date 2011
Published in FIGUIREDO-DIAS, Vilani. Fatores associados à hipovitaminose D na doença renal crônica. 2011. 103 f. Dissertação (Mestrado em Ciências) - Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, 2011.
Publisher Universidade Federal de São Paulo (UNIFESP)
Extent 103 f.
Access rights Open access Open Access
Type Dissertation
URI http://repositorio.unifesp.br/handle/11600/19159

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