Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life

Absence-like seizures in adult rats following pilocarpine-induced status epilepticus early in life

Author Ferreira, B.l.c. Autor UNIFESP Google Scholar
Valle, A.c. Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Timo-iaria, C. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Administration of pilocarpine causes epilepsy in rats if status epilepticus (SE) is induced at an early age. To determine in detail the electrophysiological patterns of the epileptogenic activity in these animals, 46 Wistar rats, 7-17 days old, were subjected to SE induced by pilocarpine and electro-oscillograms from the cortex, hippocampus, amygdala, thalamus and hypothalamus, as well as head, rostrum and vibrissa, eye, ear and forelimb movements, were recorded 120 days later. Six control animals of the same age range did not show any signs of epilepsy. In all the rats subjected to SE, iterative spike-wave complexes (8.1 ± 0.5 Hz in frequency, 18.9 ± 9.1 s in duration) were recorded from the frontal cortex during absence fits. However, similar spike-wave discharges were always found also in the hippocampus and, less frequently, in the amygdala and in thalamic nuclei. Repetitive or single spikes were also detected in these same central structures. Clonic movements and single jerks were recorded from all the rats, either concomitantly with or independently of the spike-wave complexes and spikes. We conclude that rats made epileptic with pilocarpine develop absence seizures also occurring during paradoxical sleep, showing the characteristic spike-wave bursts in neocortical areas and also in the hippocampus. This is in contrast to the well-accepted statement that one of the main characteristics of absence-like fits in the rat is that spike-wave discharges are never recorded from the hippocampal fields.
Keywords Epilepsy
Absence seizures
Status epilepticus
Language English
Date 2003-12-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 12, p. 1685-1694, 2003.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 1685-1694
Origin http://dx.doi.org/10.1590/S0100-879X2003001200010
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000187175000010
SciELO ID S0100-879X2003001200010 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/1913

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