Progress towards meningitis prevention in the conjugate vaccines era

Progress towards meningitis prevention in the conjugate vaccines era

Autor Laval, Cristina Aparecida Borges Google Scholar
Pimenta, Fabiana Cristina Google Scholar
Andrade, João Guimarães de Google Scholar
Andrade, Soraya Sgambatti Autor UNIFESP Google Scholar
Andrade, Ana Lucia S. S. de Google Scholar
Instituição Federal University of Goiás Institute of Tropical Pathology and Public Health
Universidade Federal de São Paulo (UNIFESP)
Resumo Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions.
Palavra-chave Conjugate vaccines
Hib conjugate vaccine
pneumococcal conjugate vaccine
meningococcal conjugate vaccine
impact of Hib conjugate vaccine
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Data de publicação 2003-10-01
Publicado em Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 7, n. 5, p. 315-324, 2003.
ISSN 1413-8670 (Sherpa/Romeo)
Publicador Brazilian Society of Infectious Diseases
Extensão 315-324
Fonte http://dx.doi.org/10.1590/S1413-86702003000500006
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1413-86702003000500006 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1865

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