Serum leptin concentration during puberty in healthy nonobese adolescents

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dc.contributor.author Brandao, Cynthia Maria Alvares [UNIFESP]
dc.contributor.author Lombardi, M.t. [UNIFESP]
dc.contributor.author Nishida, Sonia Kiyomi [UNIFESP]
dc.contributor.author Hauache, Omar Magid [UNIFESP]
dc.contributor.author Vieira, Jose Gilberto Henriques [UNIFESP]
dc.date.accessioned 2015-06-14T13:30:08Z
dc.date.available 2015-06-14T13:30:08Z
dc.date.issued 2003-10-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2003001000003
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 10, p. 1293-1296, 2003.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/1853
dc.description.abstract Data obtained during the past five years have indicated that there are important age- and gender-based differences in the regulation and action of leptin in humans. To study the physiological changes of leptin during puberty in both sexes, and its relationship with body composition and sexual maturation, we measured leptin concentrations in 175 healthy adolescents (80 girls, 95 boys, 10-18 years of age), representing all pubertal stages. We excluded individuals with a body mass index (BMI) below the 5thor above the 95th percentile relative to age. Serum concentrations of leptin were determined by a monoclonal antibody-based immunofluorimetric assay, developed in our laboratory. Body composition was determined by dual-energy X-ray absorptiometry. Pubertal stage was assigned by physical examination, according to Tanner criteria for breast development in females and genital development in males. Leptin concentration in girls (N = 80) presented a positive linear correlation with age (r = 0.35, P = 0.0012), BMI (r = 0.65, P < 0.0001) and %fat mass (r = 0.76, P < 0.0001). In boys (N = 95) there was a positive correlation with BMI (r = 0.49, P < 0.0001) and %fat mass (r = 0.85, P < 0.0001), but a significant negative linear correlation with Tanner stage (r = -0.45, P < 0.0001) and age (r = -0.40, P < 0.0001). The regression equation revealed that %fat mass and BMI are the best parameters to be used to estimate leptin levels in both sexes. Thus, the normal reference ranges for circulating leptin during adolescence should be constructed according to BMI or %fat mass to assure a correct evaluation. en
dc.format.extent 1293-1296
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Leptin en
dc.subject Pubertal development en
dc.subject Body composition en
dc.title Serum leptin concentration during puberty in healthy nonobese adolescents en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de Endocrinologia
dc.description.affiliationUnifesp UNIFESP, EPM, Disciplina de Endocrinologia
dc.identifier.file S0100-879X2003001000003.pdf
dc.identifier.scielo S0100-879X2003001000003
dc.identifier.doi 10.1590/S0100-879X2003001000003
dc.description.source SciELO
dc.identifier.wos WOS:000185906900004



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