Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population

Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population

Autor Munerato, Patricia Autor UNIFESP Google Scholar
Azevedo, Maria Lúcia Autor UNIFESP Google Scholar
Sucupira, Maria Cecília Araripe Autor UNIFESP Google Scholar
Pardini, Regina Autor UNIFESP Google Scholar
Pinto, Gedson Humberto Novaes Autor UNIFESP Google Scholar
Catroxo, Márcia Autor UNIFESP Google Scholar
Souza, Inara Espinelli Autor UNIFESP Google Scholar
Diaz, Ricardo Sobhie Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Entry of human immunodeficiency type 1 virus (HIV-1) into target cells requires both CD4and one of the chemokine receptors. Viruses predominantly use one, or occasionally both, of the major co-receptors CCR5 and CXCR4, although other receptors, including CCR2B and CCR3, function as minor co-receptors. A 32-nucleotide deletion (delta32) within the beta-chemokine receptor 5 gene (CCR5) has been described in subjects who remain uninfected despite extensive exposition to HIV-1. The heterozygous genotype delays disease progression. This allele is common among Caucasians, but has not been found in people of African or Asian ancestry. A more common transition involving a valine to isoleucine switch in transmembrane domain I of CCR2B (64I), with unknown functional consequences, was found to delay disease progression but not to reduce infection risk. As the Brazilian population consists of a mixture of several ethnic groups, we decided to examine the genotype frequency of these polymorphisms in this country. There were 11.5% CCR5 heterozygotes among the HIV-1 infected population and 12.5% among uninfected individuals, similar to data from North America and Western Europe. The prevalence of CCR2-64I homozygotes and heterozygotes was 0.06 and 15.2%, respectively, also similar to what is known for North America and Western Europe.
Palavra-chave CCR5
CCR2B
HIV-1 infection
polymorphisms
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data de publicação 2003-08-01
Publicado em Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 7, n. 4, p. 236-240, 2003.
ISSN 1413-8670 (Sherpa/Romeo)
Publicador Brazilian Society of Infectious Diseases
Extensão 236-240
Fonte http://dx.doi.org/10.1590/S1413-86702003000400002
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1413-86702003000400002 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1808

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