Effect of sildenafil in cavernous arteries of patients with erectile dysfunction

Effect of sildenafil in cavernous arteries of patients with erectile dysfunction

Autor Claro, Joaquim A Autor UNIFESP Google Scholar
Ximenes, Sergio Felix Autor UNIFESP Google Scholar
Nardozza Júnior, Archimedes Autor UNIFESP Google Scholar
Andrade, Enrico Autor UNIFESP Google Scholar
Messina, Leonardo Autor UNIFESP Google Scholar
Srougi, Miguel Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo INTRODUCTION: Sildenafil citrate is a type 5 phosphodiesterase inhibitor, which has demonstrated excellent results in the treatment of erectile dysfunction. The effect of sildenafil citrate in the cavernous arteries of patients with erectile dysfunction has not been established yet. The objective of this study was to assess the effect of sildenafil citrate in the cavernous arteries of patients with erectile dysfunction, following an intracavernous injection of alprostadil. MATERIALS AND METHODS: 29 male patients, with mean age of 53.8 years (32 to 75 years), were prospectively evaluated. The mean time with complaint of erectile dysfunction was 50.5 months (6 to 168 months). Each patient was his own control. Patients underwent a measurement of peak systolic velocity before and after use of sildenafil citrate associated with 5 micrograms of alprostadil, through ultrasonic velocitometry Knoll/MIDUS® system. In the interval between measurements, approximately 15 days, patients used 3 tablets of sildenafil at home with their partners. RESULTS: Using only 5 mcg of alprostadil, average peak systolic velocity was 23.9 cm/s, and when associated to 50 mg of sildenafil it was 24.8 cm/s. Despite the increase in the flow rate caused by sildenafil, the difference was not statistically significant, Zcalculated = - 0.695 NS (Wilcoxon test). Twenty one of the 29 patients (72.4%) showed global improvement in sexual performance with the use of sildenafil citrate at home. There was not a statistically significant correlation between the global response to sildenafil citrate and the increase in the peak systolic velocity. CONCLUSION: We concluded that, even though the use of 50 mg of sildenafil citrate associated with 5 mcg of alprostadil provides an increase in the peak systolic velocity of the cavernous arteries, there was no statistic difference in relation to alprostadil alone. There was no correlation between the global response to sildenafil and the increase in the peak systolic velocity
Palavra-chave penis
arteries
penile erection
corpus cavernosum
phosphodiesterases inhibitors
Idioma Inglês
Data de publicação 2003-08-01
Publicado em International braz j urol. Sociedade Brasileira de Urologia, v. 29, n. 4, p. 320-327, 2003.
ISSN 1677-5538 (Sherpa/Romeo)
Publicador Sociedade Brasileira de Urologia
Extensão 320-327
Fonte http://dx.doi.org/10.1590/S1677-55382003000400006
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1677-55382003000400006 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1791

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