Characterization of the in vivo cardiac electrophysiologic effects of high-dose cocaine in closed-chest, anesthetized dogs with normal hearts

Characterization of the in vivo cardiac electrophysiologic effects of high-dose cocaine in closed-chest, anesthetized dogs with normal hearts

Autor Fenelon, Guilherme Autor UNIFESP Google Scholar
Uchoa, Júlio Autor UNIFESP Google Scholar
Otobone, José Roberto Autor UNIFESP Google Scholar
Reis, Marcos Autor UNIFESP Google Scholar
Amaral, José Luiz Gomes do Autor UNIFESP Google Scholar
De Paola, Angelo Amato Vincenzo Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo OBJECTIVE: To characterize the cardiac electrophysiologic effects of cocaine. METHODS: In 8 dogs (9-13 kg), electrophysiologic parameters and programmed stimulation were undertaken using transvenous catheters at baseline, and after cocaine intravenous infusion (12 mg/kg bolus followed by 0.22 mg/kg/min for 25 minutes). RESULTS: Cocaine plasma levels (n=5) rose to 6.73± 0.56 mg/mL. Cocaine did not affect sinus cycle length and arterial pressure. Cocaine prolonged P wave duration (54±6 vs 73±4 ms, P<0.001), PR interval (115±17 vs 164±15 ms, P<0.001), QRS duration (62±10 vs 88±14 ms, P<0.001), and QTc interval (344±28 vs 403±62 ms, P=0.03) but not JT interval (193±35 vs 226±53 ms, NS). Cocaine prolonged PA (9±6 vs 23±8 ms, P<0.001), AH (73±16 vs 92±15 ms; P=0.03), and HV (35±5 vs 45±3ms; P<0.001) intervals and Wenckebach point (247±26 vs 280±28 ms, P=0.04). An increase occurred in atrial (138±8 vs 184± 20 ms; P<0.001) and ventricular (160±15 vs 187±25 ms; P=0.03) refractoriness at a cycle length of 300 ms. Atrial arrhythmias were not induced in any dog. Ventricular fibrillation (VF) was induced in 2/8 dogs at baseline and 4/8 dogs after cocaine. CONCLUSION: High doses of cocaine exert significant class I effects and seem to enhance inducibility of VF but not of atrial arrhythmias.
Palavra-chave cocaine
electrophysiology
ventricular fibrillation
Idioma Inglês
Data de publicação 2003-07-01
Publicado em Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 81, n. 1, p. 29-34, 2003.
ISSN 0066-782X (Sherpa/Romeo)
Publicador Sociedade Brasileira de Cardiologia - SBC
Extensão 29-34
Fonte http://dx.doi.org/10.1590/S0066-782X2003000900002
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S0066-782X2003000900002 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1776

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