Bloodstream infections in late-stage acquired immunodeficiency syndrome patients evaluated by a lysis centrifugation system

Bloodstream infections in late-stage acquired immunodeficiency syndrome patients evaluated by a lysis centrifugation system

Autor Rosas, Rc Google Scholar
Salomão, Reinaldo Autor UNIFESP Google Scholar
Matta, Daniel Archimedes da Autor UNIFESP Google Scholar
Lopes, Hv Google Scholar
Pignatari, Antonio Carlos Campos Autor UNIFESP Google Scholar
Colombo, Arnaldo Lopes Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Hospital e Maternidade Santa Marcelina
Hospital Heliópolis
Resumo Opportunistic infections, which affect acquired immunodeficiency syndrome (Aids) patients, are frequently disseminated and may cause bloodstream infections (BSI). The aim of this study was to evaluate the main causes of BSI in Aids patients with advanced stage of the disease, with special emphasis on the identification of fungemia. During a 21 months period, all patients with Aids (CD4 < 200) and febrile syndrome admitted to 3 university hospitals were systematically evaluated. For each patient presenting fever, a pair of blood cultures was collected and processed by using a commercial lysis-centrifugation system. One hundred and eleven patients (75 males) with a mean age of 36 years (median 33 years) and mean CD4 count of 64 cells/ml were included. Among the 111 patients evaluated we documented 54 episodes of BSI, including 46 patients with truly systemic infections and 8 episodes considered as contaminants. BSI were caused by gram-positive bacteria (43%), fungi (20%), gram-negative bacteria (15%), mycobacteria (15%), and mixed flora (7%). The crude mortality rate of our patients was 39%, being 50% for patients with BSI and 31% for the others. In conclusion, BSI are a common related to systemic infections on Aids patients with advanced stage of disease and is associated with a high rate of mortality.
Palavra-chave acquired immunodeficiency syndrome (Aids)
bloodstream infection
lysis centrifugation
Idioma Inglês
Data de publicação 2003-06-01
Publicado em Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 98, n. 4, p. 529-532, 2003.
ISSN 0074-0276 (Sherpa/Romeo)
Publicador Instituto Oswaldo Cruz, Ministério da Saúde
Extensão 529-532
Fonte http://dx.doi.org/10.1590/S0074-02762003000400019
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S0074-02762003000400019 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1760

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