Dietary cellulose has no effect on the regeneration of hemoglobin in growing rats with iron deficiency anemia

Dietary cellulose has no effect on the regeneration of hemoglobin in growing rats with iron deficiency anemia

Autor Catani, M. Autor UNIFESP Google Scholar
Amancio, Olga Maria Silverio Autor UNIFESP Google Scholar
Fagundes-Neto, Ulisses Autor UNIFESP Google Scholar
Morais, Mauro Batista de Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The objective of the present study was to determine the effect of cellulose on intestinal iron absorption in rats during recovery from iron deficiency anemia. Twenty-one-day-old male Wistar-EPM rats were fed an iron-free ration for two weeks to induce anemia. At 5 weeks of age, the rats were divided into two groups (both groups receiving 35 mg of elemental iron per kg diet): cellulose group (N = 12), receiving a diet containing 100 g of cellulose/kg and control (N = 12), receiving a diet containing no cellulose. The fresh weight of the feces collected over a 3-day period between the 15th and 18th day of dietary treatment was 10.7 ± 3.5 g in the group receiving cellulose and 1.9 ± 1.2 g in the control group (P<0.001). Total food intake was higher in the cellulose group (343.4 ± 22.0 g) than in the control (322.1 ± 13.1 g, P = 0.009) during the 3 weeks of dietary treatment. No significant difference was observed in weight gain (cellulose group = 132.8 ± 19.2, control = 128.0 ± 16.3 g), hemoglobin increment (cellulose group = 8.0 ± 0.8, control = 8.0 ± 1.0 g/dl), hemoglobin level (cellulose group = 12.3 ± 1.2, control = 12.1 ± 1.3 g/dl) or in hepatic iron levels (cellulose group = 333.6 ± 112.4, control = 398.4 ± 168.0 µg/g dry tissue). We conclude that cellulose does not adversely affect the regeneration of hemoglobin, hepatic iron level or the growth of rats during recovery from iron deficiency anemia.
Palavra-chave Iron deficiency
Dietary fiber
Cellulose
Iron absorption
Idioma Inglês
Data de publicação 2003-06-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 6, p. 693-697, 2003.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 693-697
Fonte http://dx.doi.org/10.1590/S0100-879X2003000600002
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000183866400002
SciELO S0100-879X2003000600002 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1719

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