Estudo eletrofisiologico da epileptogenese em animais submetidos a multiplos status epilepticus duranmte o desenvolvimento

Estudo eletrofisiologico da epileptogenese em animais submetidos a multiplos status epilepticus duranmte o desenvolvimento

Alternative title Study eletrophysiological of the epileptogenese in animals submitted to multiple status epilepticus during the development
Author Marques, Ricardo Henrique Autor UNIFESP Google Scholar
Abstract Previous experimental data have shown that neonatal seizures produces several abnormalities which persist in the aduit life. Pilocarpine-induction of consecutive status epilepticus in P7-9 rat pups of severe behavioral and eiectrographic disturbances (hippocampal and neocorticai epiieptiform discharges) in adulthood. Hippocampal slice experiments were undertaken in adult rats to explore some eietrophysiological mechanisms associated with chronic epileptogenesis in such animals. Standard extracellular recordings from CA1 area show an epileptiform responses in animals subjected to neonatal seizures These evoked responses were characterized by multiple population spikes in normal saline (3.5 mM K+). Higher potassium concentration (7.5 mM) promote increased local hyperexcitability mainly subthreshold rebount bursts and spontaneous discharges. The present data demonstrate a chronic hippocampal hyperexcitability as a consequence of multipie seizures in the neonatal period of life
Keywords Epilepsia
Pilocarpina
Hipocampo
Potássio
Ácido gama-Aminobutírico
Language Portuguese
Date 2000
Published in São Paulo: [s.n.], 2000. 78 p. ilustabgraf.
Publisher Universidade Federal de São Paulo (UNIFESP)
Extent 78 p.
Access rights Closed access
Type Dissertation
URI http://repositorio.unifesp.br/handle/11600/17093

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