Risk factors, biochemical markers, and genetic polymorphisms in early coronary artery disease

Risk factors, biochemical markers, and genetic polymorphisms in early coronary artery disease

Autor Izar, Maria Cristina de Oliveira Autor UNIFESP Google Scholar
Fonseca, Francisco Antonio Helfenstein Autor UNIFESP Google Scholar
Ihara, Silvia Saiuli Miki Autor UNIFESP Google Scholar
Kasinski, Nelson Autor UNIFESP Google Scholar
Sang, Won Han Autor UNIFESP Google Scholar
Lopes, Ieda Edite Lanzarini Autor UNIFESP Google Scholar
Pinto, Leonor do Espírito Santo de Almeida Autor UNIFESP Google Scholar
Relvas, Waldir Gabriel Miranda Autor UNIFESP Google Scholar
Lourenco, Dayse Maria Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
De Paola, Angelo Amato Vincenzo Autor UNIFESP Google Scholar
Carvalho, Antonio Carlos Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo OBJECTIVE: To assess the risk factors, lipid and apolipoprotein profile, hemostasis variables, and polymorphisms of the apolipoprotein AI-CIII gene in early coronary artery disease (CAD). METHODS: Case-control study with 112 patients in each group controlled by sex and age. After clinical evaluation and nutritional instruction, blood samples were collected for biochemical assays and genetic study. RESULTS: Familial history of early CAD (64 vs 39%), arterial hypertension (69 vs 36%), diabetes mellitus (25 vs 3%), and previous smoking (71 vs 46%) were more prevalent in the case group (p<0.001). Hypertension and diabetes were independent risk factors. Early CAD was characterized by higher serum levels of total cholesterol (235 ± 6 vs 209 ± 4 mg/dL), of LDL-c (154 ± 5 vs 135 ± 4 mg/dL), triglycerides (205 ± 12 vs 143 ± 9 mg/dL), and apolipoprotein B (129 ± 3 vs 105 ± 3 mg/dL), and lower serum levels of HDL-c (40 ± 1 vs 46 ± 1 mg/dL) and apolipoprotein AI (134 ± 2 vs 146 ± 2mg/dL) [p<0.01], in addition to an elevation in fibrinogen and D-dimer (p<0.02). The simultaneous presence of the rare alleles of the APO AI-CIII genes in early CAD are associated with hypertriglyceridemia (p=0.03). CONCLUSION: Of the classical risk factors, hypertension and diabetes mellitus were independently associated with early CAD. In addition to an unfavorable lipid profile, an increase in the thrombotic risk was identified in this population. An additive effect of the APO AI-CIII genes was observed in triglyceride levels.
Palavra-chave Coronary artery disease
risk factors
genetic polymorphisms
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data de publicação 2003-04-01
Publicado em Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 80, n. 4, p. 388-395, 2003.
ISSN 0066-782X (Sherpa/Romeo)
Publicador Sociedade Brasileira de Cardiologia - SBC
Extensão 388-395
Fonte http://dx.doi.org/10.1590/S0066-782X2003000400003
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S0066-782X2003000400003 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1691

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