Species distribution and antifungal susceptibility profile of Candida spp. bloodstream isolates from Latin American hospitals

Species distribution and antifungal susceptibility profile of Candida spp. bloodstream isolates from Latin American hospitals

Autor Godoy, Patrício Autor UNIFESP Google Scholar
Tiraboschi, Iris Nora Google Scholar
Severo, Luiz Carlos Google Scholar
Bustamante, Beatriz Google Scholar
Calvo, Belinda Google Scholar
Almeida, Leila Paula de Autor UNIFESP Google Scholar
Matta, Daniel Archimedes da Autor UNIFESP Google Scholar
Colombo, Arnaldo Lopes Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidad de Buenos Aires Hospital de Clínicas José de San Martín
Santa Casa de Porto Alegre Instituto Especializado em Pesquisa e Diagnóstico
Hospital Cayetano Heredia
Universidad del Zulia Hospital Universitário de Maracaibo
Resumo From March 1999 to March 2000, we conducted a prospective multicenter study of candidemia involving five tertiary care hospitals from four countries in Latin America. Yeast isolates were identified by classical methods and the antifungal susceptibility profile was determined according to the National Committee for Clinical Laboratory Standards microbroth assay method. During a 12 month-period we were able to collect a total of 103 bloodstream isolates of Candida spp. C. albicans was the most frequently isolated species accounting for 42% of all isolates. Non-albicans Candida species strains accounted for 58% of all episodes of candidemia and were mostly represented by C. tropicalis (24.2%) and C. parapsilosis (21.3%). It is noteworthy that we were able to identify two cases of C. lusitaniae from different institutions. In our casuistic, non-albicans Candida species isolates related to candidemic episodes were susceptible to fluconazole. Continuously surveillance programs are needed in order to identify possible changes in the species distribution and antifungal susceptibility patterns of yeasts that may occurs after increasing the use of azoles in Latin American hospitals.
Palavra-chave candidemia
antifungal susceptibility
Candida spp.
Idioma Inglês
Data de publicação 2003-04-01
Publicado em Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 98, n. 3, p. 401-405, 2003.
ISSN 0074-0276 (Sherpa/Romeo)
Publicador Instituto Oswaldo Cruz, Ministério da Saúde
Extensão 401-405
Fonte http://dx.doi.org/10.1590/S0074-02762003000300020
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S0074-02762003000300020 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1688

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