Effect of lung resection and sham surgery on the frequency of infection in alloxan-diabetic rats

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dc.contributor.author Seidel, A.c.
dc.contributor.author Fagundes, Djalma José [UNIFESP]
dc.contributor.author Bazotte, R.b.
dc.contributor.author Novo, Neil Ferreira [UNIFESP]
dc.contributor.author Juliano, Y. [UNIFESP]
dc.contributor.author Meister, H.
dc.date.accessioned 2015-06-14T13:29:57Z
dc.date.available 2015-06-14T13:29:57Z
dc.date.issued 2003-03-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2003000300001
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 3, p. 287-290, 2003.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/1673
dc.description.abstract The present study was carried out in order to determine the effect of lung resection on the frequency of infections in alloxan-diabetic rats. Adult female Wistar rats were injected with alloxan (40 mg/kg, iv) to induce diabetes mellitus (group D; N = 45) or with vehicle (1.0 ml/kg, iv) to be used as controls (group C; N = 45). Thirty-six days after receiving alloxan both groups were randomly divided into three subgroups: no operation (NO; N = 15), sham operation (SO; N = 15), and left pneumonectomy (PE; N = 15). The rats were sacrificed 36 days after surgery and their lungs were examined microscopically and macroscopically. The occurrence of thoracic wall infection, thoracic wall abscess, lung abscess and pleural empyema was similar in groups D and C. In contrast, the overall infection rate was higher (P<0.05) in the diabetic rats (SO-D and PE-D subgroups, but not in the NO-D subgroup). Considering that the overall infection rate was similar in the SO-D and PE-D subgroups, we suggest that surgery but not pneumonectomy was related to the higher prevalence of infection in diabetic rats. en
dc.format.extent 287-290
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Diabetes en
dc.subject Alloxan en
dc.subject Pneumonectomy en
dc.subject Rats en
dc.subject Infection en
dc.title Effect of lung resection and sham surgery on the frequency of infection in alloxan-diabetic rats en
dc.type Artigo
dc.contributor.institution Universidade Estadual de Maringá Departamento de Medicina
dc.contributor.institution Universidade Estadual de Maringá Departamento de Farmácia e Farmacologia
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Estadual de Maringá Departamento de Medicina
dc.description.affiliation Universidade Estadual de Maringá Departamento de Farmácia e Farmacologia
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Medicina
dc.description.affiliationUnifesp UNIFESP, EPM, Depto. de Medicina
dc.identifier.file S0100-879X2003000300001.pdf
dc.identifier.scielo S0100-879X2003000300001
dc.identifier.doi 10.1590/S0100-879X2003000300001
dc.description.source SciELO
dc.identifier.wos WOS:000181920300001



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