Effect of lung resection and sham surgery on the frequency of infection in alloxan-diabetic rats

Effect of lung resection and sham surgery on the frequency of infection in alloxan-diabetic rats

Author Seidel, A.c. Google Scholar
Fagundes, Djalma José Autor UNIFESP Google Scholar
Bazotte, R.b. Google Scholar
Novo, Neil Ferreira Autor UNIFESP Google Scholar
Juliano, Y. Autor UNIFESP Google Scholar
Meister, H. Google Scholar
Institution Universidade Estadual de Maringá Departamento de Medicina
Universidade Estadual de Maringá Departamento de Farmácia e Farmacologia
Universidade Federal de São Paulo (UNIFESP)
Abstract The present study was carried out in order to determine the effect of lung resection on the frequency of infections in alloxan-diabetic rats. Adult female Wistar rats were injected with alloxan (40 mg/kg, iv) to induce diabetes mellitus (group D; N = 45) or with vehicle (1.0 ml/kg, iv) to be used as controls (group C; N = 45). Thirty-six days after receiving alloxan both groups were randomly divided into three subgroups: no operation (NO; N = 15), sham operation (SO; N = 15), and left pneumonectomy (PE; N = 15). The rats were sacrificed 36 days after surgery and their lungs were examined microscopically and macroscopically. The occurrence of thoracic wall infection, thoracic wall abscess, lung abscess and pleural empyema was similar in groups D and C. In contrast, the overall infection rate was higher (P<0.05) in the diabetic rats (SO-D and PE-D subgroups, but not in the NO-D subgroup). Considering that the overall infection rate was similar in the SO-D and PE-D subgroups, we suggest that surgery but not pneumonectomy was related to the higher prevalence of infection in diabetic rats.
Keywords Diabetes
Alloxan
Pneumonectomy
Rats
Infection
Language English
Date 2003-03-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 3, p. 287-290, 2003.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 287-290
Origin http://dx.doi.org/10.1590/S0100-879X2003000300001
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000181920300001
SciELO ID S0100-879X2003000300001 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/1673

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