Mildly symptomatic chronic mitral regurgitation. Analysis of left ventricular systolic function and mitral regurgitant fraction under pharmacological influence: echocardiographic study

Mildly symptomatic chronic mitral regurgitation. Analysis of left ventricular systolic function and mitral regurgitant fraction under pharmacological influence: echocardiographic study

Autor Rivera, Ivan Romero Autor UNIFESP Google Scholar
Moisés, Valdir Ambrósio Autor UNIFESP Google Scholar
Carvalho, Antonio Carlos Autor UNIFESP Google Scholar
De Paola, Angelo Amato Vincenzo Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo OBJECTIVE: To study echocardiographic parameters of left ventricular systolic function and valvar regurgitation under pharmacological influence in mildly symptomatic patients with chronic mitral regurgitation (MR). METHODS: We carried out a double-blind placebo controlled study in 12 patients with MR, mean aged 12.5 years old, who were randomized in 4 phases: A) digoxin; B) enalapril; C) digoxin + enalapril; D) placebo. The medication was administered for 30 days in each phase, and the following variables were analyzed: shortening and ejection fractions, wall stress index of left ventricle, left ventricular meridional end-systolic wall stress, Doppler-derived mean rate of left ventricular pressure rise (mean dP/dt), stroke volume and MR jet area. The clinical variables analysed were heart rate and systemic arterial pressure. RESULTS: No significant variation was observed in the clinical variables analysed. The shortening and ejection fraction, the mean dP/dt and stroke volume significantly increased and the wall stress index of left ventricle, the meridional left ventricular end systolic wall stress and the mitral regurgitation jet area decreased in the phases with medication as compared with that in the placebo phase. CONCLUSION: The parameters of left ventricular systolic function improved significantly and the degree of MR decreased with the isolated administration of digoxin or enalapril in mildly symptomatic patients with chronic MR. The combination of the drugs, however, did not show better results.
Assunto echocardiography
left ventricular function
mitral regurgitation
Idioma Inglês
Financiador Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Data 2003-02-01
Publicado em Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 80, n. 2, p. 144-149, 2003.
ISSN 0066-782X (Sherpa/Romeo)
Editor Sociedade Brasileira de Cardiologia - SBC
Extensão 144-149
Fonte http://dx.doi.org/10.1590/S0066-782X2003000200003
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S0066-782X2003000200003 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/handle/11600/1653

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