A novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi

A novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi

Autor Verbisck, Newton Valério Autor UNIFESP Google Scholar
Santos, Márcia Regina Machado dos Autor UNIFESP Google Scholar
Engman, David M Google Scholar
Angel Chiurillo, Miguel Google Scholar
Ramirez, José Luis Google Scholar
Araya, Jorge Enrique Google Scholar
Mortara, Renato Arruda Autor UNIFESP Google Scholar
Franco da Silveira, José Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Northwestern University Medical School Departments of Pathology and Microbiology-Immunology
Universidad Central de Venezuela Instituto de Biologia Experimental Laboratorio de Genetica Molecular
Universidad de Antofagasta Departamento de Tecnologia Médica
Resumo We report the molecular characterization of a novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi. Steady-state level of transcripts of this sequence family appeared to be developmentally regulated, since only in the replicative forms the parasite showed expression of related sequences with a major band around 3 kb. The presence of frame shifts or premature stop codons predicts that transcripts are not translated. The sequence family also contains truncated forms of retrotransposons elements that may become potential hot spots for retroelement insertion. Sequences homologous to this family are interspersed at many chromosomes including the subtelomeric regions.
Palavra-chave Trypanosoma cruzi
interspersed repetitive DNA
transcription
retroelement insertion
subtelomeric region
Idioma Inglês
Data de publicação 2003-01-01
Publicado em Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 98, n. 1, p. 129-133, 2003.
ISSN 0074-0276 (Sherpa/Romeo)
Publicador Instituto Oswaldo Cruz, Ministério da Saúde
Extensão 129-133
Fonte http://dx.doi.org/10.1590/S0074-02762003000100016
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S0074-02762003000100016 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1640

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