Author |
Amorim, Fábio Ferreira
![]() ![]() Pinheiro, Bruno Do Vale ![]() ![]() Romaldini, Hélio ![]() ![]() |
Institution | Universidade Federal de São Paulo (UNIFESP) |
Abstract | OBJECTIVE: To analyze hemodynamic and metabolic effects of saline solution infusion in the maintenance of blood volume in ischemia-reperfusion syndrome during temporary abdominal aortic occlusion in dogs. METHODS: We studied 20 dogs divided into 2 groups: the ischemia-reperfusion group (IRG, n=10) and the ischemia-reperfusion group with saline solution infusion aiming at maintaining mean pulmonary arterial wedge pressure between 10 and 20 mmHg (IRG-SS, n=10). All animals were anesthetized with sodium thiopental and maintained on spontaneous ventilation. Occlusion of the supraceliac aorta was obtained with inflation of a Fogarty catheter inserted through the femoral artery. After 60 minutes of ischemia, the balloon was deflated, and the animals were observed for another 60 minutes of reperfusion. RESULTS: IRG-SS dogs did not have hemodynamic instability after aortic unclamping, and the mean systemic blood pressure and heart rate were maintained. However, acidosis worsened, which was documented by a greater reduction of arterial pH that occurred especially due to the absence of a respiratory response to metabolic acidosis that was greater with the adoption of this procedure. CONCLUSION: Saline solution infusion to maintain blood volume avoided hemodynamic instability after aortic unclamping. This procedure, however, caused worsening in metabolic acidosis in this experimental model. |
Keywords |
reperfusion lesion
hemodynamic volemia |
Language | English |
Date | 2002-10-01 |
Published in | Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 79, n. 4, p. 400-404, 2002. |
ISSN | 0066-782X (Sherpa/Romeo) |
Publisher | Sociedade Brasileira de Cardiologia - SBC |
Extent | 400-404 |
Origin |
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Access rights | Open access ![]() |
Type | Article |
SciELO ID | S0066-782X2002001300007 (statistics in SciELO) |
URI | http://repositorio.unifesp.br/handle/11600/1527 |
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