Sawtooth waves during REM sleep after administration of haloperidol combined with total sleep deprivation in healthy young subjects

Sawtooth waves during REM sleep after administration of haloperidol combined with total sleep deprivation in healthy young subjects

Author Pinto Junior, L.R. Autor UNIFESP Google Scholar
Peres, Clovis de Araujo Autor UNIFESP Google Scholar
Russo, Regina Helena Autor UNIFESP Google Scholar
Remesar-Lopez, Alberto Jorge Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract We sought to examine the possible participation of dopaminergic receptors in the phasic events that occur during rapid eye movement (REM) sleep, known as sawtooth waves (STW). These phasic phenomena of REM sleep exhibit a unique morphology and, although they represent a characteristic feature of REM sleep, little is known about the mechanisms which generate them and which are apparently different from rapid eye movements. STW behavior was studied in 10 male volunteers aged 20 to 35 years, who were submitted to polysomnographic monitoring (PSG). On the adaptation night they were submitted to the first PSG and on the second night, to the basal PSG. On the third night the volunteers received placebo or haloperidol and spent the whole night awake. On the fourth night they were submitted to the third PSG. After a 15-day rest period, the volunteers returned to the sleep laboratory and, according to a double-blind crossover randomized design, received haloperidol or placebo and spent the whole night awake, after which they were submitted to the fourth PSG. The volunteers who were given haloperidol combined with sleep deprivation exhibited an elevation of the duration and density of the STW, without significant alterations of the other REM sleep phasic phenomena such as rapid eye movement. These findings suggest that sawtooth waves must have their own generating mechanisms and that the dopaminergic receptors must exert a modulating role since REM sleep deprivation, as well as administration of neuroleptics, produces supersensitivity of dopaminergic receptors.
Keywords Sawtooth waves
REM sleep
Sleep deprivation
Dopaminergic receptors
Rapid eye movements
Haloperidol
Language English
Date 2002-05-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 5, p. 599-604, 2002.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 599-604
Origin http://dx.doi.org/10.1590/S0100-879X2002000500013
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000175800900013
SciELO ID S0100-879X2002000500013 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/1418

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