Proconvulsant effects of high doses of venlafaxine in pentylenetetrazole-convulsive rats

Proconvulsant effects of high doses of venlafaxine in pentylenetetrazole-convulsive rats

Autor Santos-Junior, Jair Guilherme Autor UNIFESP Google Scholar
Do Monte, F.h.m. Google Scholar
Russi, M. Google Scholar
Agustine, P.e. Google Scholar
Lanziotti, Vanusa Maria Nascimento Bispo Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade do Estado de Santa Catarina Centro de Ciências Agroveterinárias Departamento de Morfofisiologia
Resumo Venlafaxine, an atypical antidepressant drug, has been used to treat several neurological disorders, presenting excellent efficacy and tolerability. Clinical seizures after venlafaxine treatment have occasionally been reported when the drug was used at very high doses or in combination with other medications. The aim of the present study was to investigate the convulsant effects of venlafaxine in rats under controlled laboratory conditions. Adult male Wistar rats (8 per group) receiving venlafaxine or saline at the doses of 25-150 mg/kg were subjected 30 min later to injections of pentylenetetrazole at the dose of 60 mg/kg. The animals receiving 75, 100 and 150 mg/kg venlafaxine presented increased severity of convulsion when compared to controls (P = 0.02, P = 0.04, and P = 0.0004, respectively). Indeed, an increased percentage of death was observed in these groups (50, 38, and 88%, respectively) when compared to the percentage of death in the controls (0%). The group receiving 150 mg/kg showed an reduction in death latency (999 ± 146 s) compared to controls (1800 ± 0 s; cut-off time). Indeed, in this group, all animals developed seizures prior to pentylenetetrazole administration. Surprisingly, the groups receiving venlafaxine at the doses of 25 and 50 mg/kg showed a tendency towards an increase in the latency to the first convulsion. These findings suggest that venlafaxine at doses of 25 and 50 mg/kg has some tendency to an anticonvulsant effect in the rat, whereas doses of 75, 100 and 150 mg/kg presented clear proconvulsant effects in rats submitted to the pentylenetetrazole injection. These findings are the first report in the literature concerning the role of venlafaxine in seizure genesis in the rat under controlled conditions.
Palavra-chave Antidepressant
Venlafaxine
Convulsion
Epilepsy
Pentylenetetrazole
Idioma Inglês
Data de publicação 2002-04-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 4, p. 469-472, 2002.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 469-472
Fonte http://dx.doi.org/10.1590/S0100-879X2002000400010
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000175259700010
SciELO S0100-879X2002000400010 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1411

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