Pharmacological Therapy for Myocardial Infarction in the Elderly: An 8-year Analysis

Pharmacological Therapy for Myocardial Infarction in the Elderly: An 8-year Analysis

Autor Makdisse, Márcia Regina Pinho Autor UNIFESP Google Scholar
Matsushita, Andrea de M. Autor UNIFESP Google Scholar
Gonçalves Júnior, Iran Autor UNIFESP Google Scholar
Miranda, Odete Autor UNIFESP Google Scholar
Gomes, Ana Cristina Autor UNIFESP Google Scholar
Cartocci, Monica M. Autor UNIFESP Google Scholar
Covre, Silvia Autor UNIFESP Google Scholar
Carvalho, Antonio Carlos Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo OBJECTIVE:To assess the changes in the medicamentous treatment of elderly patients hospitalized with acute myocardial infarction occurring over an 8-year period. METHODS:We retrospectively analyzed 379 patients above the age of 65 years with acute myocardial infarction who were admitted to the coronary unit of a university-affiliated hospital from 1990 to 1997. The patients were divided into 2 groups, according to the period of time of hospital admission as follows: group 1 - from 1990 to 1993; and group 2 - from 1994 to 1997. RESULTS:The use of beta-blockers (40.8%chi 75.2%, p<0.0001) and angiotensin-converting enzyme inhibitors (42% chi59.5%, p=0.001) was significantly greater in group 2, while the use of calcium antagonists (42% chi 18.5%, p<0.0001) and general antiarrhythmic drugs (19.1% chi 10.8%, p=0.03) was significantly lower. No significant difference was observed in regard to the use of acetylsalicylic acid, thrombolytic agents, nitrate, and digitalis in the period studied. The length of hospitalization was shorter in group 2 (13.4±8.9 days chi 10.5±7.5 days, p<0.001). The in-hospital mortality was 35.7% in group 1 and 26.6% in group 2 (p=0.07). CONCLUSION: Significant changes were observed in the treatment of elderly patients with acute myocardial infarction, with a greater use of beta-blockers and angiotensin-converting enzyme inhibitors and a lower use of calcium antagonists and antiarrhythmic drugs in group 2. The length of hospitalization and the mortality rate were also lower in group 2, even though the reduction in mortality was not statistically significant.
Palavra-chave myocardial infarction
Idioma Inglês
Data de publicação 2002-04-01
Publicado em Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 78, n. 4, p. 369-373, 2002.
ISSN 0066-782X (Sherpa/Romeo)
Publicador Sociedade Brasileira de Cardiologia - SBC
Extensão 369-373
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S0066-782X2002000400003 (estatísticas na SciELO)
Endereço permanente

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