Author |
Faria, Alessandra Nunes
![]() ![]() Ribeiro Filho, Fernando Flexa ![]() ![]() Lerário, Daniel Diniz G. ![]() ![]() Kohlmann, Narcia Elisa Bellucci ![]() ![]() Ferreira, Sandra Roberta Gouvea ![]() ![]() Zanella, Maria Teresa ![]() ![]() |
Institution | Universidade Federal de São Paulo (UNIFESP) |
Abstract | OBJECTIVE: To assess the effects of weight reduction with 10mg of sibutramine or placebo on blood pressure during 24 hours (ambulatory blood pressure monitoring), on left ventricular mass, and on antihypertensive therapy in 86 obese and hypertensive patients for 6 months. METHODS: The patients underwent echocardiography, ambulatory blood pressure monitoring, and measurement of the levels of hepatic enzymes prior to and after treatment with sibutramine or placebo. RESULTS: The group using sibutramine had a greater weight loss than that using placebo (6.7% versus 2.5%; p<0.001), an increase in heart rate (78.3±7.3 to 82±7.9 bpm; p=0.02), and a reduction in the left ventricular mass/height index (105±29.3 versus 96.6±28.58 g/m; p=0.002). Both groups showed similar increases in the levels of alkaline phosphatase and comparable adjustments in antihypertensive therapy; blood pressure, however, did not change. CONCLUSION: The use of sibutramine caused weight loss and a reduction in left ventricular mass in obese and hypertensive patients with no interference with blood pressure or with antihypertensive therapy. |
Keywords |
sibutramine
obesity arterial hypertension |
Language | English |
Date | 2002-02-01 |
Published in | Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 78, n. 2, p. 176-180, 2002. |
ISSN | 0066-782X (Sherpa/Romeo) |
Publisher | Sociedade Brasileira de Cardiologia - SBC |
Extent | 176-180 |
Origin |
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Access rights | Open access ![]() |
Type | Article |
SciELO ID | S0066-782X2002000200006 (statistics in SciELO) |
URI | http://repositorio.unifesp.br/handle/11600/1342 |
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