Effects of Sibutramine on the Treatment of Obesity in Patients with Arterial Hypertension

Effects of Sibutramine on the Treatment of Obesity in Patients with Arterial Hypertension

Author Faria, Alessandra Nunes Autor UNIFESP Google Scholar
Ribeiro Filho, Fernando Flexa Autor UNIFESP Google Scholar
Lerário, Daniel Diniz G. Autor UNIFESP Google Scholar
Kohlmann, Narcia Elisa Bellucci Autor UNIFESP Google Scholar
Ferreira, Sandra Roberta Gouvea Autor UNIFESP Google Scholar
Zanella, Maria Teresa Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract OBJECTIVE: To assess the effects of weight reduction with 10mg of sibutramine or placebo on blood pressure during 24 hours (ambulatory blood pressure monitoring), on left ventricular mass, and on antihypertensive therapy in 86 obese and hypertensive patients for 6 months. METHODS: The patients underwent echocardiography, ambulatory blood pressure monitoring, and measurement of the levels of hepatic enzymes prior to and after treatment with sibutramine or placebo. RESULTS: The group using sibutramine had a greater weight loss than that using placebo (6.7% versus 2.5%; p<0.001), an increase in heart rate (78.3±7.3 to 82±7.9 bpm; p=0.02), and a reduction in the left ventricular mass/height index (105±29.3 versus 96.6±28.58 g/m; p=0.002). Both groups showed similar increases in the levels of alkaline phosphatase and comparable adjustments in antihypertensive therapy; blood pressure, however, did not change. CONCLUSION: The use of sibutramine caused weight loss and a reduction in left ventricular mass in obese and hypertensive patients with no interference with blood pressure or with antihypertensive therapy.
Keywords sibutramine
arterial hypertension
Language English
Date 2002-02-01
Published in Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 78, n. 2, p. 176-180, 2002.
ISSN 0066-782X (Sherpa/Romeo)
Publisher Sociedade Brasileira de Cardiologia - SBC
Extent 176-180
Origin http://dx.doi.org/10.1590/S0066-782X2002000200006
Access rights Open access Open Access
Type Article
SciELO ID S0066-782X2002000200006 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/1342

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