Ventilation with high tidal volume induces inflammatory lung injury

Ventilation with high tidal volume induces inflammatory lung injury

Autor Bueno, Patricia Cincotto dos Santos Autor UNIFESP Google Scholar
Bueno, Carlos Eduardo Autor UNIFESP Google Scholar
Santos, Manuel Lopes dos Autor UNIFESP Google Scholar
Oliveira-Júnior, Itamar Souza Autor UNIFESP Google Scholar
Salomão, Reinaldo Autor UNIFESP Google Scholar
Pinheiro, Bruno do Valle Autor UNIFESP Google Scholar
Beppu, Osvaldo Shigueomi Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Mechanical ventilation with high tidal volumes (V T) has been shown to induce lung injury. We examined the hypothesis that this procedure induces lung injury with inflammatory features. Anesthetized male Wistar rats were randomized into three groups: group 1 (N = 12): V T = 7 ml/kg, respiratory rate (RR) = 50 breaths/min; group 2 (N = 10): V T = 21 ml/kg, RR = 16 breaths/min; group 3 (N = 11): V T = 42 ml/kg, RR = 8 breaths/min. The animals were ventilated with fraction of inspired oxygen of 1 and positive end-expiratory pressure of 2 cmH2O. After 4 h of ventilation, group 3, compared to groups 1 and 2, had lower PaO2 [280 (range 73-458) vs 517 (range 307-596), and 547 mmHg (range 330-662), respectively, P<0.05], higher wet lung weight [3.62 ± 0.91 vs 1.69 ± 0.48 and 1.44 ± 0.20 g, respectively, P<0.05], and higher wet lung weight/dry lung weight ratio [18.14 (range 11.55-26.31) vs 7.80 (range 4.79-12.18), and 6.34 (range 5.92-7.04), respectively, P<0.05]. Total cell and neutrophil counts were higher in group 3 compared to groups 1 and 2 (P<0.05), as were baseline TNF-alpha concentrations [134 (range <10-386) vs 16 (range <10-24), and 17 pg/ml (range <10-23), respectively, P<0.05]. Serum TNF-alpha concentrations reached a higher level in group 3, but without statistical significance. These results suggest that mechanical ventilation with high V T induces lung injury with inflammatory characteristics. This ventilatory strategy can affect the release of TNF-alpha in the lungs and can reach the systemic circulation, a finding that may have relevance for the development of a systemic inflammatory response.
Palavra-chave Lung injury
Mechanical ventilation
Inflammation
TNF-alpha
Idioma Inglês
Data de publicação 2002-02-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 2, p. 191-198, 2002.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 191-198
Fonte http://dx.doi.org/10.1590/S0100-879X2002000200007
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000174281400007
SciELO S0100-879X2002000200007 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/1341

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